AI Article Synopsis
- - The study explores using corn protein-based microneedles (ZMNs) for delivering vaccines transdermally, providing a less invasive alternative to traditional injections.
- - ZMN application was found to be safer, with lower bacterial skin penetration compared to hypodermic needles, and the antigens remained stable under various storage conditions.
- - Results showed that ZMN delivery led to significantly higher antibody responses compared to control groups, suggesting that these microneedles could effectively facilitate vaccine administration.
Article Abstract
Transcutaneous antigen administration provides an alternative to invasive syringe injections. The objective of this study was to investigate the feasibility of fabrication and antigen delivery using microneedles made from corn protein, zein. Micromolding technique was used to cast cone-shaped zein microneedles (ZMNs). The insertion of ZMNs and the delivery of the model antigen, ovalbumin (OVA), into the skin was confirmed by histological examination and confocal microscopy. In addition, a significantly ( < 0.05) lower bacterial skin penetration was observed after ZMN application compared with hypodermic syringe application. OVA coated on ZMNs was stable after storage under ambient and refrigerator conditions. Transcutaneous immunization studies showed significantly ( < 0.001) greater antibody titers (total IgG, IgG1, and IgG2a) after the application of OVA-coated ZMNs and OVA intradermal injection compared with the control group. Taken together, antigen-coated ZMNs can be developed for transcutaneous vaccine delivery.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044761 | PMC |
| http://dx.doi.org/10.1021/acsomega.7b00343 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!