Nucleotides cAMP, cUTP and beta NAD were tested for antiproliferative activity in HeLa and HEP2 cell cultures. The tests conducted at different stages of cell culturing established a relationship between the proliferative response of cells, on the one hand, and the dosage and time of injection of nucleotide into cell culture, on the other. In the cAMP series, the injection of a minimal dose at the time of inoculation was followed by inhibition of cell growth, as shown by the proliferative index. However, the maximum concentration of cAMP produced a pronounced stimulating effect on the cell growth of both lines. Neither cUTP nor beta NAD injected in the dose used in the study changed the proliferative activity of cells, as compared with control.
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