AI Article Synopsis
- Allogeneic stem cell transplantation (alloSCT) using homozygous CCR5 Δ32 stem cells previously led to a cure for HIV infection.
- Recently, a case of viral breakthrough was reported after a similar transplantation, indicating potential relapse.
- The quick resurgence of the virus post-transplant was linked to a highly replicative CXCR4-tropic HIV variant that was present before the transplantation occurred.
Article Abstract
Allogeneic stem cell transplantation (alloSCT) of homozygous CCR5 Δ32 stem cells once resulted in the cure of human immunodeficiency virus (HIV) infection. We have recently reported a viral breakthrough in a similar setting. Here, we demonstrate that the rapid rebound after alloSCT was related to a highly replicative CXCR4-tropic HIV variant, which could already be detected before alloSCT.
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| http://dx.doi.org/10.1093/cid/ciy565 | DOI Listing |
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