The diastereoselective synthesis of fluorinated building blocks that contain chiral fluorine substituents is of interest. Here we describe optimisation efforts in the synthesis of -2,3-difluorobutane-1,4-diol, as well as the synthesis of the corresponding -diastereomer. Both targets were synthesised using an epoxide opening strategy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753060 | PMC |
| http://dx.doi.org/10.3762/bjoc.13.280 | DOI Listing |
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