Tidal Disruption Events (TDEs) are processes where stars are torn apart by the strong gravitational force near to a massive or supermassive black hole. If a jet is launched in such a process, particle acceleration may take place in internal shocks. We demonstrate that jetted TDEs can simultaneously describe the observed neutrino and cosmic ray fluxes at the highest energies if stars with heavier compositions, such as carbon-oxygen white dwarfs, are tidally disrupted and these events are sufficiently abundant. We simulate the photo-hadronic interactions both in the TDE jet and in the propagation through the extragalactic space and we show that the simultaneous description of Ultra-High Energy Cosmic Ray (UHECR) and PeV neutrino data implies that a nuclear cascade in the jet is developed by photo-hadronic interactions.
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http://dx.doi.org/10.1038/s41598-018-29022-4 | DOI Listing |
Drug Alcohol Depend Rep
March 2025
Institute for Drug and Alcohol Studies, Virginia Commonwealth University, 203 East Cary Street, Richmond, VA 23219, USA.
Background: Evidence supports the common incidence of sleep disturbance in opioid use disorder (OUD) as a potential marker of disrupted orexin system functioning. This study evaluated the initial safety and tolerability of a challenge dose of lemborexant, a dual orexin antagonist, as an adjunct to buprenorphine/naloxone.
Methods: Patients (18-65 years old) with OUD receiving sublingual buprenorphine/naloxone, with a Pittsburgh Sleep Quality Index total score of 6 or higher, were recruited from outpatient clinics.
Front Physiol
December 2024
Department of Neuroscience, Baylor College of Medicine, Houston, TX, United States.
Increasing evidence indicates an association between microbiome composition and respiratory homeostasis and disease, particularly disordered breathing, such as obstructive sleep apnea. Previous work showing respiratory disruption is limited by the methodology employed to disrupt, eliminate, or remove the microbiome by antibiotic depletion. Our work utilized germ-free mice born without a microbiome and described respiratory alterations.
View Article and Find Full Text PDFNat Commun
December 2024
Astronomical Institute, Czech Academy of Sciences, Boční II 1401, Prague, 141 00, Czech Republic.
High-velocity stars and peculiar G objects orbit the central supermassive black hole (SMBH) Sagittarius A* (Sgr A*). Together, the G objects and high-velocity stars constitute the S cluster. In contrast with theoretical predictions, no binary system near Sgr A* has been identified.
View Article and Find Full Text PDFMol Ecol
February 2025
Marine Science Center and Coastal Sustainability Institute, Northeastern University, Nahant, Massachusetts, USA.
Changes in genetic variation, and particularly documented declines in genetic diversity, influence not only evolutionary potential but also current ecological function. Given this context, it is essential to understand what abiotic and biotic factors promote or disrupt the maintenance of genetic variation in natural populations. To address this knowledge gap in the context of salt marsh plants, we established a three-year field experiment, testing the independent and interactive effects of nutrient availability and physical stress on the maintenance of plant (Spartina alterniflora) genotypic diversity.
View Article and Find Full Text PDFMol Ther
December 2024
Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address:
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