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The inverse association between the apolipoprotein E ε4 allele and C-reactive protein levels is stronger in persons with obesity and diabetes.
Scand J Immunol
January 2024
Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Article Synopsis
- C-reactive protein (CRP) levels are lower in individuals with the APOEε4 allele, potentially influenced by factors like body mass index (BMI), diabetes, and statin use.
- The study analyzed 2,700 older adults to explore the connection between CRP levels and APOEε4 status while considering BMI, diabetes, and statin medication.
- Results showed that APOEε4 carriers had higher CRP levels regardless of BMI, diabetes, or statin use, indicating that CRP response to inflammation may differ in these individuals, highlighting implications for neurodegenerative and cardiovascular diseases.
Within-person reproducibility of proteoforms related to inflammation and renal dysfunction.
Sci Rep
May 2022
Bevital AS, Jonas Lies veg 87, 5021, Bergen, Norway.
Protein biomarkers and microheterogeneity have attracted increasing attention in epidemiological and clinical research. Knowledge of within-person reproducibility over time is paramount to determine whether a single measurement accurately reflects an individual's long-term exposure. Yet, research investigating within-person reproducibility for proteoforms is limited.
View Article and Find Full Text PDFMicroheterogeneity and preanalytical stability of protein biomarkers of inflammation and renal function.
Talanta
February 2021
Bevital AS, Jonas Lies veg 87, Laboratory building, 5021, Bergen, Norway.
Protein biomarker microheterogeneity has attracted increasing attention in epidemiological and clinical research studies. Knowledge concerning the preanalytical stability of proteins is paramount to assess the biological significance of their proteoforms. We investigated the stability of the inflammatory markers C-reactive protein (CRP), serum amyloid A (SAA), and calprotectin (S100A8/9), and the renal function marker, cystatin C (CnC).
View Article and Find Full Text PDFImmuno-MALDI-TOF-MS in the Clinic.
Clin Chem
September 2018
Segal Cancer Proteomics Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada;
Multiplex Immuno-MALDI-TOF MS for Targeted Quantification of Protein Biomarkers and Their Proteoforms Related to Inflammation and Renal Dysfunction.
Anal Chem
March 2018
Department of Clinical Science , University of Bergen, 5021 Bergen , Norway.
Circulating proteins are widely used as biomarkers in clinical applications for the diagnosis, prediction, and treatment of numerous diseases. Immunoassays are the most common technologies for quantification of protein biomarkers and exist in various formats. Traditional immunoassays offer sensitive and fast analyses but cannot differentiate between proteoforms.
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