AI Article Synopsis
- Synaptic plasticity is key to understanding learning and memory in the adult human brain, but studying it is challenging due to limited access to live human neurons.
- Research methods have yielded insights into the properties and plasticity of adult human synapses, uncovering some surprising findings.
- This text explores experimental approaches, mechanisms of Hebbian spike timing-dependent plasticity (STDP), and how these principles relate to human learning and memory.
Article Abstract
Synaptic plasticity is the cellular basis of learning and memory, but to what extent this holds for the adult human brain is not known. To study synaptic plasticity in human neuronal circuits poses a huge challenge, since live human neurons and synapses are not readily accessible. Despite this, various lines of research have provided insights in properties of adult human synapses and their plasticity both in vitro and in vivo, with some unexpected surprises. We first discuss the experimental approaches to study activity-dependent plasticity of adult human synapses, and then highlight rules and mechanisms of Hebbian spike timing-dependent plasticity (STDP) found in these synapses. Finally, we conclude with thoughts on how these synaptic principles can underlie human learning and memory.
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| http://dx.doi.org/10.1016/j.conb.2018.06.013 | DOI Listing |
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