Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ejso.2018.05.039 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
PET Quantification in Healthy Humans of Cyclooxygenase-2, a Potential Biomarker of Neuroinflammation.
J Nucl Med
January 2025
Intramural Research Program, National Institute of Mental Health, Bethesda, Maryland;
Cyclooxygenase-2 (COX-2) is present in a healthy brain at low densities but can be markedly upregulated by excitatory input and by inflammogens. This study evaluated the sensitivity of the PET radioligand [C]-6-methoxy-2-(4-(methylsulfonyl)phenyl)--(thiophen-2-ylmethyl)pyrimidin-4-amine ([C]MC1) to detect COX-2 density in a healthy human brain. The specificity of [C]MC1 was confirmed using lipopolysaccharide-injected rats and transgenic mice expressing the human gene, with 120-min baseline and blocked scans using COX-1 and COX-2 selective agents.
View Article and Find Full Text PDFLutetium-177 labeled iPD-L1 as a novel immunomodulator for cancer-targeted radiotherapy.
EJNMMI Radiopharm Chem
January 2025
Department of Radioactive Materials, Instituto Nacional de Investigaciones Nucleares, Ocoyoacac, 52750, Mexico.
Background: Cancer immunotherapy is a relatively new approach to cancer treatment. Peptides that target specific pathways and cells involved in immunomodulation can potentially improve the efficacy of cancer therapy. Recently, we reported iPD-L1 as a novel inhibitor peptide that specifically targets the cancer cell ligand PD-L1 (programmed death ligand 1).
View Article and Find Full Text PDFDispersion behavior of Fukushima-derived Cs over the North Pacific with emphasis on its sensitivity to vertical velocity and diffusion.
Mar Pollut Bull
January 2025
Ocean Environment Institute, Oceanic Consulting and Trading, Seoul, Republic of Korea.
This study simulated the dispersion of Cs in the North Pacific using a Lagrangian particle model, incorporating basin-wide atmospheric deposition and direct release from the Fukushima accident. Three experiments examined the impact of vertical diffusion and velocity on dispersion behavior. EXP01 and EXP02 assumed zero vertical velocity with different vertical diffusion coefficients (1 × 10 and 2 × 10 m/s, respectively), while EXP03 used a 3-day average vertical velocity and the same diffusion coefficient as EXP01.
View Article and Find Full Text PDFMarine and atmospheric transport modeling supporting nuclear preparedness in Norway: Recent achievements and remaining challenges.
Sci Total Environ
January 2025
Center for Environmental Radioactivity (CERAD) CoE, Norwegian University of Life Sciences, P.O. Box 5003, N-1432 Ås, Norway; Faculty of Environmental Sciences and Natural Resource Management, Norwegian University of Life Sciences (NMBU), P.O.Box 5003, NO-1432 Ås, Norway.
Numerical transport models are important tools for nuclear emergency decision makers in that they rapidly provide early predictions of dispersion of released radionuclides, which is key information to determine adequate emergency protective measures. They can also help us understand and describe environmental processes and can give a comprehensive assessment of transport and transfer of radionuclides in the environment. Transport of radionuclides in air and ocean is affected by a number of different physico-chemical processes.
View Article and Find Full Text PDFFunctionalization of layered double hydroxides on bentonite for cesium and iodine retention in high-level radioactive waste disposal.
Chemosphere
February 2025
Division of Advanced Nuclear Engineering, POSTECH, 77, Cheongam-ro, Nam-gu, Pohang, South Korea; Division of Environmental Science & Engineering, POSTECH, 77, Cheongam-ro, Nam-gu, Pohang, South Korea. Electronic address:
Bentonite is regarded as an adequate buffer material in deep geological repositories and its swelling properties serve to prevent the penetration of groundwater into the repository and to minimize the release of radionuclides. However, bentonite is rarely effective in removing anionic radionuclides due to its permanent negative surface charge. The aim of this study was to enhance the anion removal ability of bentonite by incorporating layered double hydroxides (LDH) with a high anion exchange capacity.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!