Objectives: Cellular schwannoma that occurs in the spine is relatively rare. Herein, we retrospectively analyzed the clinical and imaging data from nine cases of spinal cellular schwannoma.
Materials And Methods: The clinical, imaging data and pathological manifestations were retrospectively analyzed from nine cases of pathologically confirmed spinal cellular schwannoma.
Results: All nine cases were treated with surgical excision; seven cases were solitary lesions characterized by a dumbbell-shaped soft tissue mass growing out across the intervertebral foramen and two cases were multiple nodular lesions in the spinal canal. Six cases had compressive bony destruction, one case displayed osteolytic and compressive bony destruction, and two cases were without apparent bony destruction. Computed Tomography (CT)scans showed three cases were isodense and two cases were miscellany density. Magnetic Resonance Imaging (MRI) scans showed that the solid part of the tumor was isointense on the T1-weighted imaging (T1WI); five cases were isointense and three cases were slightly hyperintense on T2-weighted imaging (T2WI). Five cases exhibited hyperintense cystic regions. MRI enhanced scanning showed that 3/7 cases showed moderately to markedly heterogeneous enhancement and the remaining 4/7 cases showed markedly homogeneous enhancement. Except for one recurrence, 8/9 cases had a good prognosis.
Conclusion: Spinal cellular schwannoma should be diagnosed combining the imaging manifestation with clinical performance and pathological examination in order to distinguish it from other tumors, such as classical schwannoma and malignant peripheral nerve sheath tumors.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ejrad.2018.05.025 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Therapeutic effect of novel drug candidate, PRG-N-01, on NF2 syndrome-related tumor.
Neuro Oncol
December 2024
Department of Molecular Biology, College of Natural Science, Pusan National University, Busan, Republic of Korea.
Background: NF2-related schwannomatosis (NF2-SWN) is associated with multiple benign tumors in the nervous system. NF2-SWN, caused by mutations in the NF2 gene, has developed into intracranial and spinal schwannomas. Because of the high surgical risk and frequent recurrence of multiple tumors, targeted therapy is necessary.
View Article and Find Full Text PDFSpinally targeted paired associated stimulation with high-frequency peripheral component induces spinal level plasticity in healthy subjects.
Sci Rep
December 2024
BioMag Laboratory, HUS Diagnostic Center, Helsinki University Hospital, University of Helsinki and Aalto University School of Science, Helsinki, Finland.
A novel variant of paired-associative stimulation (PAS) consisting of high-frequency peripheral nerve stimulation (PNS) and high-intensity transcranial magnetic stimulation (TMS) above the motor cortex, called high-PAS, can lead to improved motor function in patients with incomplete spinal cord injury. In PAS, the interstimulus interval (ISI) between the PNS and TMS pulses plays a significant role in the location of the intended effect of the induced plastic changes. While conventional PAS protocols (single TMS pulse often applied with intensity close to resting motor threshold, and single PNS pulse) usually require precisely defined ISIs, high-PAS can induce plasticity at a wide range of ISIs and also in spite of small ISI errors, which is helpful in clinical settings where precise ISI determination can be challenging.
View Article and Find Full Text PDFConotoxin KM-RIIIJ reveals interplay between K1-channels and persistent sodium currents in proprioceptive DRG neurons.
Sci Rep
December 2024
School of Biological Sciences, University of Utah, Salt Lake City, Utah, USA.
Voltage-gated potassium channels (VGKCs) comprise the largest and most complex families of ion channels. Approximately 70 genes encode VGKC alpha subunits, which assemble into functional tetrameric channel complexes. These subunits can also combine to form heteromeric channels, significantly expanding the potential diversity of VGKCs.
View Article and Find Full Text PDFForsythoside B Ameliorates Neuroinflammation via Inhibiting NLRP3 Inflammasome of Glial Cells in Experimental Autoimmune Encephalomyelitis Mice.
Brain Res Bull
December 2024
Department of Neurology, the First Affiliated Hospital of Hainan Medical University, Haikou 570102, China. Electronic address:
Neuroinflammation mediated by glial cells plays a crucial role in demyelination in experimental autoimmune encephalomyelitis (EAE), a multiple sclerosis (MS) model. Forsythoside B (FTS·B), a natural phenylethanoid glycoside isolated from the dried fruits and leaves of Forsythia suspensa (Thunb.) Vahl, has been found to have antioxidant, anti-apoptotic, and anti-inflammatory properties.
View Article and Find Full Text PDFDifferentiating multiple sclerosis with predominant spinal cord and optic nerve involvement from other autoimmune demyelinating diseases using B cell immunophenotyping and gene expression profiling.
Mult Scler Relat Disord
December 2024
Istanbul University, Aziz Sancar Institute for Experimental Medical Research, Department of Neuroscience, Istanbul, Turkiye.
Objective: Multiple sclerosis (MS) may present with predominant involvement of the spinal cord and optic nerve (MS/w-SCON) and mimic other autoimmune inflammatory demyelinating disorders (AIDD) such as neuromyelitis optica spectrum disorder (NMOSD), and relapsing inflammatory optic neuritis (RION). Thus, biomarkers are required for effective differential diagnosis of AIDD.
Methods: Patients with MS/w-SCON (n = 20), MS without involvement of SCON (MS/wo-SCON) (n = 22), NMOSD (n = 16), RION (n = 15) and healthy individuals (n = 21) were included.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!