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Effect of restrictive versus liberal fluid therapy for laparoscopic gastric surgery on postoperative complications: a randomized controlled trial.
J Anesth
December 2024
Department of Anesthesiology, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-machi, Takatsuki, Osaka, 569-8686, Japan.
Purpose: Currently, laparoscopic surgery is a standard technique in the field of abdominal surgery. However, the most adequate fluid regimen during laparoscopic surgery remains unclear. The aim of this trial is to compare a restricted fluid therapy with a liberal fluid therapy for laparoscopic abdominal surgery.
View Article and Find Full Text PDFPurified Granulocyte Concentrates from Buffy Coats with Extended Storage Time.
Transfus Med Hemother
December 2024
Artcline GmbH, Rostock, Germany.
Article Synopsis
- Granulocyte concentrates (GCs) can be made from pooled buffy coats of whole blood donations, allowing for better availability and longer storage times compared to those made from single-donor apheresis, which can only last 24 hours.
- A process was developed to significantly reduce red blood cell and platelet contamination, extending the shelf life of GCs up to 72 hours while maintaining high cell viability (above 98%) and functionality (with over 95% rates of phagocytosis and oxidative burst).
- To produce a therapeutic dose of GCs, around 15-20 buffy coats are needed, offering a more efficient alternative for treatment compared to traditional methods.
Comparison of anticoagulant combinations used in granulocyte apheresis.
Transfus Apher Sci
December 2024
Hacettepe University Medical Faculty, Department of Internal Medicine Division of Hematology, Ankara, Turkey; Hacettepe University Medical Faculty Hospitals Blood Center and Apheresis Unit, Ankara, Turkey. Electronic address:
Our study retrospectively examines the number of granulocytes in the products of donors who donated granulocytes between January 2016 and September 2020 at the Hacettepe University Faculty of Medicine Blood Bank. The effects of acid-citrate-dextrose (ACD), trisodium citrate + hydroxyethyl starch (TCC + HES) and ACD + HES combinations used in the apheresis procedure on the granulocyte count of apheresis products were examined. As a result of study, it was seen that the type of anticoagulant combination used during apheresis significantly affected the number of granulocytes collected.
View Article and Find Full Text PDFEfficacy of 6% Hydroxyethyl Starch and 2% Lidocaine in Reducing the Pain of Propofol Injection: A randomised, placebo-controlled trial.
Sultan Qaboos Univ Med J
November 2024
Department of Radiation Oncology, All India Institute of Medical Sciences, Raebareli, India.
Article Synopsis
- This study investigated whether administering Hydroxyethyl starch (HES) before propofol could reduce pain during propofol injection, as HES is known to inhibit pain-related pathways in the body.
- Conducted as a randomized, placebo-controlled trial in India with 339 elective surgery patients, participants were divided into three groups: one receiving HES, another with normal saline and lidocaine, and a placebo group with normal saline only.
- Results showed that significantly more patients in the HES group reported no pain (75 patients) compared to the lidocaine (33 patients) and placebo (13 patients) groups, with overall pain levels being lowest in the HES group.
Three Is a Magic Number: Tailored Clickable Chelators Used to Determine Optimal RGD-Peptide Multiplicity in αvβ6-Integrin Targeted Lu-Labeled Cancer Theranostics.
Bioconjug Chem
December 2024
TRIMT GmbH, Carl-Eschebach-Str. 7, 01454 Radeberg, Germany.
The cellular adhesion receptor αvβ6-integrin is highly expressed in many cancers, e.g., pancreatic, lung, head-and-neck, cervical, bladder, and esophageal carcinoma.
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