AI Article Synopsis
- The Catellani reaction is an important method for quickly creating complex substituted arenes that are hard to make with traditional methods.
- It uses a combination of palladium and norbornene catalysis to enable a two-step process that modifies aryl iodides efficiently in one go.
- The review covers advancements in the field, particularly focusing on various alkylating agents and their uses in organic synthesis, aiming to motivate further research and innovation.
Article Abstract
The Catellani reaction is a powerful strategy that allows the expeditious synthesis of highly substituted arenes, which are not easily accessible through traditional transition-metal-catalyzed cross-coupling reactions. This reaction utilizes the synergistic interplay of palladium and norbornene catalysis to facilitate sequential ortho-C-H functionalization and ipso termination of aryl iodides in a single operation. Since pioneering work by the group of Catellani in 1997, and later by the group of Lautens, this chemistry has attracted considerable attention from the synthetic chemistry community. Dramatic progress has been made by a number of groups in the past two decades. In this Minireview, the alkylating reagents employed in this intriguing reaction and the corresponding applications in organic synthesis are summarized; thus complementing existing reviews to inspire future developments.
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| http://dx.doi.org/10.1002/chem.201802818 | DOI Listing |
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