AI Article Synopsis
- Achieved selective hydroalkylation of ynone, ynoate, and ynamide using dual catalysis with Ni and Ir under light, yielding valuable trisubstituted enones.
- The reaction was highly efficient, focusing on forming α/Z isomers, which adds to existing β-alkylation methods.
- The resulting trisubstituted enones can be further modified into more useful compounds through subsequent reactions.
Article Abstract
Exclusively α- and highly E/ Z-selective hydroalkylation of ynone, ynoate, and ynamide was achieved via photoredox mediated Ni/Ir dual catalysis with high atom and step economy, producing trisubstituted enones, which are versatile synthetic building blocks. The developed reaction selectively delivered the α/ Z isomer, which is complementary to the previously reported β-alkylation processes. The trisubstituted enones could be transformed to more valuable compounds via post-functionalization.
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| http://dx.doi.org/10.1021/acs.orglett.8b02017 | DOI Listing |
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