Ervadivamines A (1) and B (2), two unprecedented trimeric monoterpenoid indole alkaloids, were isolated from Ervatamia divaricata. They are the first examples of vobasine-iboga-vobasine-type alkaloid with both C-C and C-N linkage patterns. Their structures including absolute configurations were fully accomplished by extensive spectroscopic analysis, single-crystal X-ray diffraction, and electric circular dichroism methods. The plausible biogenetic pathways of these trimeric alkaloids were also proposed. In addition, compound 1 exhibited significant cytotoxicity against four cancer cells.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.joc.8b01371 | DOI Listing |
Publication Analysis
Top Keywords
trimeric monoterpenoid
8
monoterpenoid indole
8
indole alkaloids
8
ervatamia divaricata
8
ervadivamines unusual
4
unusual trimeric
4
alkaloids ervatamia
4
divaricata ervadivamines
4
ervadivamines unprecedented
4
unprecedented trimeric
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!