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Drug Development.
Alzheimers Dement
December 2024
Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Background: Clinical trials should strive to yield results that are clinically meaningful rather than solely relying on statistical significance. However, the determination of clinical meaningfulness of dementia clinical trials lacks standardization and varies based on the trial's nature. To tackle this issue, a proposed approach involves assessing the time saved before reaching a specific threshold in cognitive status.
View Article and Find Full Text PDFBackground: The LatAm-FINGERS trial marks a pioneering initiative as the first non-pharmacological clinical trial encompassing participants from 12 Latin American countries, including Argentina, Brazil, Bolivia, Chile, Colombia, Costa Rica, Ecuador, Dominican Republic, Mexico, Peru, Puerto Rico, and Uruguay. This initiative represents a significant advancement in promoting inclusivity and diversity in clinical trial recruitment, particularly in underserved populations.
Method: The LatAm-FINGERS trial is a multicenter randomized clinical trial evaluating a lifestyle intervention tailored for the Latin American population.
Dementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
University College London, London, London, United Kingdom.
Background: People with dementia have complex palliative care needs including psycho-social, physical and spiritual; however, they are often unmet. It is important to empower people with dementia, family caregivers and professionals to work together to better assess and monitor ongoing needs. This study aimed to co-design and test the feasibility of an integrated model of palliative dementia care to support holistic assessment and decision making for care in the community and care homes (assisted living facilities).
View Article and Find Full Text PDFThe prevalence of Alzheimer's disease and related disorders (ADRD) is rising, and primary care providers (PCPs) will increasingly play a role in its detection. We developed an evidence-based intervention to facilitate cognitive evaluation in primary care. We then implemented it as a set of web-based trainings which were combined with specific tools embedded in the electronic health record (EHR) for PCPs to use in their practices.
View Article and Find Full Text PDFDementia Care Practice.
Alzheimers Dement
December 2024
Riphah International University, Islamabad, Punjab, Pakistan.
Integrating balance and cognitive training of varied intensities through exergame balance training may offer a distinct approach to enhancing balance and cognitive abilities in patients with mild cognitive impairment. The objective is to determine the relationship and effects of exergame balance training of different intensities on balance and cognition in patients with mild cognitive impairment (MCI). In this four-arm parallel design Randomized Clinical Trial, ninety-seven participants with mild cognitive impairments MoCA (18-24), between the ages of 50 and 75 years, participated in novel exergame balance training.
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