AI Article Synopsis
- The study aimed to assess how photobiomodulation (PBM) affects testicular tissues and sperm quality in mice with type one diabetes induced by streptozotocin (STZ).
- Two groups of mice received different PBM treatments (0.03 J/cm and 0.2 J/cm), resulting in improved metrics like Sertoli and Leydig cell counts, and longer seminiferous tubules compared to control mice.
- The group receiving the higher PBM energy density (0.2 J/cm) showed significantly better sperm count and motility than both the control and lower energy PBM groups, indicating PBM's potential therapeutic effects.
Article Abstract
The aim of this study was to evaluate the effect of photobiomodulation (PBM) on testicular tissues and fresh sperm analysis factors in streptozotocin (STZ)-induced type one diabetes mellitus (T1DM) mice. T1DM was induced in 15 male Syrian mice by injection of 200 mg/kg STZ. After one month, mice were divided randomly into three groups, harboring 5 mice each: 1, control group; 2, first laser group (890 nm, 80 Hz, 0.03 J/cm) and 3, second laser group (0.2 J/cm). Then the mice were euthanized and testicles were dissected for stereological studies, and both epididymis and vas deferens were removed for fresh sperm analysis. Data were analyzed by statistical methods. A significant increase was observed in the Sertoli cell count in both PBM groups, compared to the control group. In addition, the second PBM group shows a significant increase in the Sertoli cell count, compared to the first PBM group. Both PBM groups show significant increase in the Leydig cell count, compared to the control group. There were significant increases of the length in the seminiferous tubules in both PBM groups, compared to the control group. In addition, the second PBM group showed a significant increase of the length in the seminiferous tubules, compared to the first PBM group. The second PBM group showed a significant increase in the sperm count, compared to the control, and first PBM groups. The first PBM group showed a significant increase in sperm count, compared to the control group. The sperm motility and count were significantly increased in the second PBM group, compared to the control and first PBM groups. The sperm motility was significantly increased in the first PBM group, compared to the control group. PBM with 0.2 J/cm and 0.03 J/cm energy densities significantly improved the stereological parameters and fresh sperm analysis factors, compared to the control group in STZ-induced T1DM in mice. Moreover, the PBM with 0.2 J/cm energy density was statistically more effective, compared to the 0.03 J/cm.
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| http://dx.doi.org/10.1016/j.jphotobiol.2018.06.018 | DOI Listing |
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