Hereditary component of variation in Sr deposition in inbred mice under exogenous conditions that affect bone formation.

Bone-seeking radionuclides (specifically Sr) accumulate in the bone tissue and act as a long-term source of internal irradiation. Their behaviour in the body has been studied in detail, while the impact of inheritance has not been established. On one hand, the genetic determination of both skeletal morphology and calcium metabolism is indirect evidence that the kinetics of deposition of alkaline-earth radioisotopes in the skeleton also have a hereditary component. On the other hand, analysis of Sr kinetics in different inbred mouse strains did not reveal any differences between the mice. This study used a classical approach to evaluating the hereditary component of variation in quantitative traits, namely, a variant of familial analysis (the method of twin families). The growth of the skeleton is known to be accompanied by distinct changes in Sr accumulation. That is why the hereditary (familial) component of variation in Sr kinetics in the bone tissue of CBA mice was analyzed under the influences that modify growth processes Individual parameters of Sr accumulation differed between experimental groups by a factor of 2-4.5. At the same time, features of Sr accumulation proved to be characteristic of entire families. The results show that the intrafamilial correlation in Sr deposition in the skeleton is highly significant (R = 0.542, P ≤ 0.0001) and comparable to that of morphological parameters (R = 0.532-0.546, P ≤ 0.0001). The results confirm the existence of statistically significant intrafamilial correlations of weight and metabolic parameters, which is similarly expressed in different families, thereby providing evidence for hereditary determination of Sr metabolism. At the same time, the stability of Sr metabolism inheritance to changes in morphophysiology and environmental influences (including those close to pathogenic ones) is shown. This is evidence of its authenticity and significance. The results obtained can be extrapolated to humans instead of directly analyzing the role of hereditary factors in the metabolism of toxic compounds, which are difficult and unethical to perform in human subjects.