Two new compounds herialpins A-B (-), along with eleven known compounds, were isolated from the culture of fungus . The structures were elucidated by 1D and 2D NMR data, ESI-MS and X-ray crystallographic analysis. Compounds - were assayed for their cytotoxicity against three tumor cell lines compared with the known compound . Compounds and were found with modest activity, while compound exhibits stronger selective inhibitory activity against A549 and HT-29 cells with IC values of 15.1 and 20.1 μmol/L, respectively. The pyrano[3,4-]chromene-4,6-dione moiety in compound should be responsible for the stronger selective inhibitory activity.
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