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A surge in female condom distribution during the COVID-19 pandemic in Gauteng province, South Africa.
Contracept Reprod Med
January 2025
School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Background: Female Condoms are 90-95% effective against HIV transmission when correctly and consistently used and are also cost-effective. In general, condoms prevent sexually transmitted infections (STIs) and unwanted pregnancies. Although the COVID-19 pandemic had the potential to undermine routine healthcare services delivery and utilisation, there is limited evidence about the pandemic's effect on Female Condom uptake in Gauteng, one of the hardest-hit provinces in South Africa.
View Article and Find Full Text PDFCorrecting mitochondrial loss mitigates NOTCH1-related aortopathy in mice.
Nat Cardiovasc Res
January 2025
Shanghai Fifth People's Hospital and Institutes of Biomedical Sciences Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Loss-of-function mutations in NOTCH1 were previously linked to thoracic aortopathy, a condition for which non-surgical treatment options are limited. Based on clinical proteome analysis, we hypothesized that mitochondrial fusion and biogenesis in aortic smooth muscle cells (SMCs) are crucial for regulating the progression of NOTCH1-related aortopathy. Here we demonstrate that SMC-specific Notch1 knockout mice develop aortic pathology, including stiffening, dilation and focal dissection.
View Article and Find Full Text PDFSuccessful Long-Term Management of NF1 Congenital Tibial Dysplasia with Prophylactic Bypass Graft and Bracing: A Case Report.
JBJS Case Connect
October 2024
Department of Orthopaedics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Case: An 8-year-old girl with NF1 and congenital tibial dysplasia with significant bilateral tibial bowing underwent McFarland procedures. Now age 22 with 14-year follow-up indicating sustained correction and healing of her bilateral limb deformities.
Conclusion: This case illustrates the McFarland procedure provided adequate corrective treatment of this deformity and remains a success at long-term follow-up.
Relationship between sexually transmitted infections knowledge and the sexual behavior of Brazilian future doctors.
Front Med (Lausanne)
December 2024
Medical College, Bahiana School of Medicine and Public Health, Salvador, Brazil.
Background: The prevalence of sexually transmitted infections (STIs) remains alarming, especially among young people and college students, highlighting the vulnerability of this population. In the academic context, it is worth investigating whether medical students, despite their access to information, also engage in risky sexual behaviors.
Objective: The present study aims to describe the sexual behavior of Brazilian medical students, analyzing their level of knowledge about HIV/AIDS and other STIs, as well as examining potential correlations between this knowledge and risky behaviors.
Evaluating the home-based intervention strategy (HIS-UK) to reduce new chlamydia infection among young men aged 16-25 years by promoting correct and consistent condom use: findings from a randomised controlled trial.
BMC Health Serv Res
December 2024
Brighton and Sussex Clinical Trials Unit, University of Sussex, Brighton, UK.
Background: Correct and consistent condom use is the most effective method to reduce transmission of sexually transmitted infections (STIs).
Objective: To compare the HIS-UK intervention to usual condom information and distribution care for effect on chlamydia test positivity.
Methods: Trial design A 3-parallel arm randomised controlled trial (1:1:1 allocation, two intervention arms vs.
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