AI Article Synopsis
- The study explored retinal vessel oxygen saturation levels in patients with mild cognitive impairment (MCI) compared to healthy individuals.
- Oxygen saturation levels were found to be higher in both arterioles and venules of MCI patients, indicating possible changes in oxygen metabolism.
- The research suggests that MCI may lead to less effective oxygen extraction in retinal tissue, highlighting potential metabolic changes associated with the condition.
Article Abstract
Introduction: We have previously reported that retinal vessel oxygen saturation is increased in mild-to-moderate dementia of Alzheimer's type when compared with healthy individuals. Mild cognitive impairment (MCI) is the predementia stage of the disease. The main purpose was to investigate if these changes are seen in MCI.
Methods: Retinal vessel oxygen saturation was measured in 42 patients with MCI and 42 healthy individuals with a noninvasive retinal oximeter, Oxymap T1. The groups were paired according to age.
Results: Arteriolar and venular oxygen saturation was increased in MCI patients compared to healthy individuals (arterioles: 93.1 ± 3.7% vs. 91.1 ± 3.4%, = .01; venules: 59.6 ± 6.1% vs. 54.9 ± 6.4%, = .001). Arteriovenous difference was decreased in MCI compared to healthy individuals (33.5 ± 4.5% vs. 36.2 ± 5.2%, = .01).
Discussion: Increased retinal vessel oxygen saturation and decreased arteriovenous difference in MCI could reflect less oxygen extraction by retinal tissue. This indicates that retinal oxygen metabolism may be affected in patients with MCI.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024244 | PMC |
| http://dx.doi.org/10.1016/j.dadm.2018.03.002 | DOI Listing |
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