We report the emergence of colistin resistance in carbapenemase (KPC)-producing after 8 days of colistin-based therapy, resulting in relapse of bloodstream infection and death. Disruption of the gene by insertion of a mobile genetic element was found to be the mechanism, which was replicated in vitro after exposure to subinhibitory concentrations of colistin and meropenem.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913667 | PMC |
| http://dx.doi.org/10.1093/ofid/ofy054 | DOI Listing |
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