AI Article Synopsis
- * Her serum creatinine level was critically high at 7.44 mg/dL, indicating severe kidney dysfunction, but she fully recovered and was discharged with a normal level of 0.68 mg/dL.
- * The case highlights the need for better awareness and caution among physicians when prescribing valacyclovir to elderly patients, especially regarding their renal function and potential management strategies.
Article Abstract
A 66-year-old women with no history of renal disease was admitted due to a coma and acute kidney injury with a serum creatinine level of 7.44 mg/dL which were ascribed to valacyclovir neurotoxicity and nephrotoxicity, respectively. She had received valacyclovir at a standard dosage for the treatment of herpes zoster and was finally discharged, having fully returned to her normal baseline mental status with a recovered serum creatinine level of 0.68 mg/dL. We feel that awareness of this pathology remains a challenge for physicians and therefore strongly recommend the further accumulation of experiences similar to our own. Our experience underscores the pitfalls of administering valacyclovir to elderly patients who barely appear to have a favorable renal function. Several concerns regarding the therapeutic management, including blood purification strategies, that emerged in this case are also discussed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043912 | PMC |
| http://dx.doi.org/10.1177/1177392818782899 | DOI Listing |
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