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View Article and Find Full Text PDFArticle Synopsis
- The study explores the causal relationship between circulating inflammatory proteins (CIPs) and four types of spinal degenerative diseases (SDDs), using Mendelian randomization to assess this connection.
- Various genetic data were analyzed for CIPs and SDDs, employing methods like inverse variance weighted to ensure the validity of the findings and to examine reverse causality.
- Results revealed specific CIPs that could either increase or decrease the risk of conditions like cervical spondylosis and prolapsed discs, suggesting potential genetic targets for further research in understanding the mechanisms behind SDDs.
Mendelian Randomization Analysis of Circulating Cytokines and Risk of Autoimmune Neuroinflammatory Diseases.
Immunotargets Ther
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Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, People's Republic of China.
Background: Cytokines act a vital role in autoimmune neuroinflammatory diseases (ANDs) with undetermined causal relationships. Mendelian randomization (MR) analysis was performed to estimate the causal effects of circulating levels of cytokines on the risk of ANDs.
Methods: The causal relationship between 34 circulating cytokines and 4 kinds of ANDs, including multiple sclerosis (MS), neuromyelitis optica (NOM), chronic inflammatory demyelinating polyneuropathy (CIDP) and myasthenia gravis (MG) were explored using four methods of MR analysis.
Effect of Incomplete Cryoablation and Matrix Metalloproteinase Inhibition on Intratumoral CD8 T-Cell Infiltration in Murine Hepatocellular Carcinoma.
Radiology
February 2024
From the Department of Radiology and Biomedical Imaging (A.S., J.G.S., D.N., J.T., S.K.M., D.C., J.D., D.C.M., J.C.), Section of Digestive Diseases, Department of Internal Medicine (S.J.R., J.C.), Section of Medical Oncology, Department of Medicine (D.C.M.), and Section of Surgical Oncology, Department of Surgery (D.C.M.), Yale University School of Medicine, 300 Cedar St, The Anlyan Center, N312A, New Haven, CT 06520; Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany (A.S., A.W.); Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität, Berlin, Germany (A.B., V.K.); Department of Biomedical Engineering, School of Engineering & Applied Science, Yale University, New Haven, Conn (D.C., J.D., J.C.); and Department of Diagnostic and Interventional Radiology and Neuroradiology, Asklepios Clinic Altona, Hamburg, Germany (A.W.).
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