Novel Polyketides Produced by the Endophytic Fungus from .

Molecules

The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory, Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

Published: July 2018

Five new polyketides, including two pairs of enantiomers and a racemate, were isolated from the fermentation broth of , an endophytic fungus isolated from . Their structures were identified using one-dimensional (1D) and two-dimensional (2D) NMR experiments, and the absolute configurations of the enantiomers were confirmed using electronic circular dichroism (ECD) calculations. Compounds and exhibited inhibitory activity against the MV4-11 cell line in vitro, with IC values of 23.95 µM and 32.70 µM, respectively.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100219PMC
http://dx.doi.org/10.3390/molecules23071709DOI Listing

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