Five new polyketides, including two pairs of enantiomers and a racemate, were isolated from the fermentation broth of , an endophytic fungus isolated from . Their structures were identified using one-dimensional (1D) and two-dimensional (2D) NMR experiments, and the absolute configurations of the enantiomers were confirmed using electronic circular dichroism (ECD) calculations. Compounds and exhibited inhibitory activity against the MV4-11 cell line in vitro, with IC values of 23.95 µM and 32.70 µM, respectively.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100219 | PMC |
http://dx.doi.org/10.3390/molecules23071709 | DOI Listing |
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