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Investigating the efficacy of gellan gum hydrogel films infused with Acacia stingless bee honey in wound healing.
Int J Biol Macromol
January 2025
Faculty of Science and Marine Environment, Universiti Malaysia Terengganu, 21030, Terengganu, Malaysia. Electronic address:
Effective wound healing requires biocompatible and functional wound dressings. This study explores the synergistic potential of gellan gum (GG), known for its exceptional gel-forming abilities, and acacia stingless bee honey (SBH), for its potent antioxidant properties, in developing advanced wound care solutions. GG hydrogel films incorporated with varying concentrations of SBH (v/v) at 10 % (GGSBH10), 15 % (GGSBH15), and 20 % (GGSBH20) were characterized.
View Article and Find Full Text PDFHarnessing the Power of Our Immune System: The Antimicrobial and Antibiofilm Properties of Nitric Oxide.
Microorganisms
December 2024
Advanced Wound Care Research & Development, Convatec, Deeside Industrial Park, Deeside CH5 2NU, UK.
Nitric oxide (NO) is a free radical of the human innate immune response to invading pathogens. NO, produced by nitric oxide synthases (NOSs), is used by the immune system to kill microorganisms encapsulated within phagosomes via protein and DNA disruption. Owing to its ability to disperse biofilm-bound microorganisms, penetrate the biofilm matrix, and act as a signal molecule, NO may also be effective as an antibiofilm agent.
View Article and Find Full Text PDFPhotoactive broad-spectrum dressings with antimicrobial and antitumoral properties.
Biomater Adv
December 2024
Instituto de Investigaciones en Tecnologías Energéticas y Materiales Avanzados (IITEMA), Universidad Nacional de Río Cuarto and Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Campus Universitario, 5800 Río Cuarto, Argentina. Electronic address:
In this work the development of photoactive dressings (PAD) with dual purpose, is presented. These PAD can be used for the topical treatment of persistent infections caused by fungi and bacteria and are also applicable in light antitumor therapy for carcinoma. The synthesized PAD were designed employing conjugated polymer nanoparticles (CPN) doped with platinum porphyrin which serve as polymerization photoinitiators and photosensitizers for the production of reactive oxygen species (ROS).
View Article and Find Full Text PDFGlucantime and quercetin electrospun nanofiber membranes: Fabrication and their evaluation as dressing for cutaneous leishmaniasis.
Mol Biochem Parasitol
December 2024
Department of Clinical Pharmacy, School of Pharmacy, Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran. Electronic address:
Cutaneous leishmaniasis is considered as one of the most concerns of the World Health Organization (WHO). The main objective of this study was to use polycaprolactone (PCL) nanofiber scaffolds in order to provide a topical drug delivery system capable of delivering glucantime (glu) and quercetin (qur) to cutaneous leishmaniasis wounds. First, PCL/glu/qur, PCL/glu, and PCL/qur nanofibers were prepared by an electrospinning method followed by characterization through scanning electron microscopy (SEM) and fourier transform infrared spectroscopy (FTIR).
View Article and Find Full Text PDFImproved Technique Reduce Lower Limb Complications After the Traditional No-Touch Technique for Vein Graft Harvesting: A Single-Center Retrospective Historical Controlled Study.
J Multidiscip Healthc
November 2024
Department of Physiology, Hebei Medical University, Shijiazhuang, 050000, People's Republic of China.
Objective: The employment of the no-touch technique in harvesting the great saphenous vein (GSV) for coronary artery bypass grafting has been associated with a significant improvement in clinical patency rates. Despite these advantages, such grafts may predispose patients to complications in the lower limbs. This study endeavors to evaluate the incidence of complications in the lower extremities by deploying an enhanced protocol for the no-touch harvesting technique.
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