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RabGTPase is a member of the Ras superfamily of small GTPases, which share a GTP-binding pocket containing highly conserved motifs that promote GTP hydrolysis. In Arabidopsis, the RabA group, which corresponds to the Rab11 group in animals, functions in the recycling of endosomes that control docking and fusion during vesicle transport. However, their molecular mechanisms remain unknown. In this study, we determined the crystal structures of the GDP-bound inactive form and both GppNHp- and GTP-bound active forms of RabA1a, at resolutions of 2.8, 2.6, and 2.6 Å, respectively. A bound sulfate ion in the active site of the GDP-bound structure stabilized Switch II by bridging the interaction between a magnesium ion and Arg74. Comparisons of the two states of RabA1a with Rab11 proteins revealed clear differences in the Switch I and II loops. These results suggested that conformational change of the Switch regions of RabA1a, derived by GTP or GDP binding, could maintain subcellular membrane traffic through the specific interaction of effector molecules.
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http://dx.doi.org/10.1111/jipb.12700 | DOI Listing |
ACS Nano
December 2024
Department of Chemistry, Burke Laboratory, Dartmouth College, Hanover, New Hampshire 03755, United States.
This paper describes the use of the layered conductive metal-organic framework (MOF) (nickel)-(hexahydroxytriphenylene) [Ni(HHTP)] as a model system for understanding the process of self-assembly within this class of materials. We confirm and quantify experimentally the role of the oxidant in the synthetic process. Monitoring the deposition of Ni(HHTP) with infrared spectroscopy revealed that MOF formation is characterized by an initial induction period, followed by linear growth with respect to time.
View Article and Find Full Text PDFJ Phys Chem Lett
December 2024
Key Laboratory for Thermal Science and Power Engineering of Ministry of Education, Department of Energy and Power Engineering, Tsinghua University, Beijing 100084, People's Republic of China.
Ice formation from water vapor is a common phenomenon with significant implications for both natural ice formation and industrial processes. However, there remains controversy over how deposition frequency and substrate temperature affect the structural forms of deposition products and their formation processes. In this study, we employed molecular dynamics simulations to investigate the deposition process of water vapor onto a cold Au(001) substrate at different temperatures and deposition frequencies.
View Article and Find Full Text PDFTaking into account phase-polarization interactions is crucial for the formation of spatially structured laser beams. The effects that arise in this context can lead to the modulation of individual field components and the transformation of the overall light field. In this study, we investigate the impact of phase and polarization distributions with radial dependencies in polar coordinates on the longitudinal component of laser beams passing through a transmissive spatial light modulator (SLM) based on twisted nematic liquid crystals.
View Article and Find Full Text PDFActa Crystallogr D Struct Biol
January 2025
SR Life Science Instrumentation Team, RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5198, Japan.
Recent advances in low-emittance synchrotron X-ray technology and highly sensitive photon-counting detectors have revolutionized protein micro-crystallography in structural biology. These developments and improvements to sample-exchange robots and beamline control have paved the way for automated and efficient unattended data collection. This study analyzed protein crystal structures such as type 2 angiotensin II receptor, CNNM/CorC membrane proteins and polyhedral protein crystals using small-wedge synchrotron crystallography (SWSX), which dramatically improves measurement efficiency through automated measurement.
View Article and Find Full Text PDFTalanta
December 2024
Thin Films and Materials Science Research Laboratory, Department of Physics, Dayanand Science College, Latur, Maharashtra, 413512, India. Electronic address:
In this study, we report the synthesis, optical characterization and ultra-sensitive ammonia gas sensing properties of Mg-doped ZnO cauliflower like nanostructures obtained via chemical spray pyrolysis technique. The morphological and structural properties of the prepared films were investigated by Field Emission Scanning electron microscope (FESEM) and X-ray diffraction (XRD). Gas sensing and optical characterizations were carried out using Keithley electrometer and Uv-Vis.
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