AI Article Synopsis
- Pancreatic cancer is one of the deadliest forms of cancer, and current treatments often struggle because patient outcomes can't be accurately predicted.
- The study presents S100A10 as a new biomarker that not only can help predict patient survival and recurrence but also plays a role in promoting tumor growth and invasion.
- S100A10 is found at higher levels in pancreatic tumors compared to normal tissue, and its expression is influenced by methylation and the oncogene KRAS, making it a promising target for improving patient outcomes.
Article Abstract
Pancreatic cancer is arguably the deadliest cancer type. The efficacy of current therapies is often hindered by the inability to predict patient outcome. As such, the development of tools for early detection and risk prediction is key for improving outcome and quality of life. Here, we introduce the plasminogen receptor S100A10 as a novel predictive biomarker and a driver of pancreatic tumor growth and invasion. We demonstrated that S100A10 mRNA and protein are overexpressed in human pancreatic tumors compared to normal ducts and nonductal stroma. S100A10 mRNA and methylation status were predictive of overall survival and recurrence-free survival across multiple patient cohorts. S100A10 expression was driven by promoter methylation and the oncogene KRAS. S100A10 knockdown reduced surface plasminogen activation, invasiveness, and in vivo growth of pancreatic cancer cell lines. These findings delineate the clinical and functional contribution of S100A10 as a biomarker in pancreatic cancer.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210040 | PMC |
| http://dx.doi.org/10.1002/1878-0261.12356 | DOI Listing |
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