AI Article Synopsis
- A novel chitosan conduit was created for repairing peripheral nerves, featuring a double-layered porous design that offers optimal mechanical and chemical properties.
- Efficacy was tested by bridging a 10-mm nerve gap in Lewis rats, comparing the new conduit to standard inverted nerve autografts after 12 weeks.
- The chitosan conduit showed strong regenerative abilities, facilitating blood vessel formation and proper nerve cell alignment due to its engineered structure and properties.
Article Abstract
A novel freeze-cast porous chitosan conduit for peripheral nerve repair with highly-aligned, double layered porosity, which provides the ideal mechanical and chemical properties was designed, manufactured, and assessed in vivo. Efficacies of the conduit and the control inverted nerve autograft were evaluated in bridging 10-mm Lewis rat sciatic nerve gap at 12 weeks post-implantation. Biocompatibility and regenerative efficacy of the porous chitosan conduit were evaluated through the histomorphometric analysis of longitudinal and transverse sections. The porous chitosan conduit was found to have promising regenerative characteristics, promoting the desired neovascularization, and axonal ingrowth and alignment through a combination of structural, mechanical and chemical cues.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044444 | PMC |
| http://dx.doi.org/10.1557/adv.2018.194 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!