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Ultrasound-controllable dexamethasone-loaded nanobubbles for highly effective rheumatoid arthritis therapy.
J Mater Chem B
January 2025
Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an, 710032, China.
Rheumatoid arthritis (RA) is an autoimmune disease that seriously threatens human health and affects the quality of life of patients. At present, pharmacotherapy is still the mainstream treatment for RA, but most methods have shortcomings, such as poor drug targeting, a low effective drug dosage at the inflammatory site, and high systemic toxicity. The combined application of drug-loaded nanobubbles and ultrasound technology provides a new technique for the treatment of RA.
View Article and Find Full Text PDFMulti-Layered Microneedles Loaded with Microspheres.
AAPS PharmSciTech
January 2025
School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, Georgia, 30332-0100, U.S.A..
Delivery of therapies into skin is attractive for medical indications including vaccination and treatment of dermatoses but is highly constrained by the stratum corneum barrier. Microneedle (MN) patches have emerged as a promising technology to enable non-invasive, intuitive, and low-cost skin delivery. When combined with biodegradable polymer formulations, MN patches can further enable controlled-release drug delivery without injection.
View Article and Find Full Text PDFQuality-by-design principles applied to the development and optimisation of lidocaine-loaded dissolving microneedle arrays - a proof-of-concept.
Drug Deliv Transl Res
January 2025
Leicester Institute of Pharmaceutical, Health and Social Care Innovations, Leicester School of Pharmacy, De Montfort University, Leicester, LE1 9BH, UK.
The use of dissolving microneedle arrays (dMNA) for intradermal and transdermal drug delivery has been a growing trend in the field for the past decades. However, a lack of specific regulatory standards still hinders their clinical development and translation to market. It is also well-known that dMNA composition significantly impacts their performance, with each new formulation potentially presenting a challenge for developers, manufacturers and regulatory agencies.
View Article and Find Full Text PDFiRGD-TRP-PK1-modified red blood cell membrane vesicles as a new chemotherapeutic drug delivery and targeting system in head and neck cancer.
Theranostics
January 2025
The Second Affiliated Hospital, School of Medicine, The Chinese University of Hong Kong, Shenzhen & Longgang District People's Hospital of Shenzhen, Shenzhen, 518172, China.
Chemotherapy is essential for treating tumors, including head and neck cancer (HNC). However, the toxic side effects of chemotherapeutic drugs limit their widespread use. Therefore, a targeted delivery system that can transport the drug to the pathological site while minimizing damage to healthy tissues is urgently needed.
View Article and Find Full Text PDFMedium molecular weight chitosan and magnetite based bead as a nanocomposite for delivery of anticancer drug: Development, evaluation and biocompatibility study.
Int J Biol Macromol
December 2024
Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India. Electronic address:
Article Synopsis
- The study focuses on using magnetic nanoparticles (MNP) combined with chitosan to improve targeted drug delivery for breast cancer treatment, aiming for better efficacy and fewer side effects.
- MNPs were created through a co-precipitation method, and then encapsulated with the anti-cancer drug 5-fluorouracil (5-FU) in chitosan beads, followed by a variety of characterization techniques to confirm their properties.
- Results indicated a high entrapment efficiency of 85-90% and notable cytotoxic effects on breast cancer cells, with drug release varying under different pH levels, suggesting a promising strategy for targeted cancer therapy.
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