[Proper oral health can protect from developing gingival hyperplasia induced by calcium channel blockers].

Orv Hetil

Farmakológiai és Farmakoterápiai Intézet, Pécsi Tudományegyetem, Általános Orvostudományi Kar Pécs, Szigeti út 12., 7624.

Published: July 2018

Cardiovascular diseases including hypertension affect 40% of the adult population in Hungary. Calcium channel blockers are frequently prescribed for the treatment of hypertension either in monotherapy or in fixed-combination therapy. Their main effect is vasodilatation with gingival hyperplasia as a side effect. Our aim is to draw our colleagues' attention to the practical importance of the fact that calcium channel blocker-induced gingival hyperplasia correlates closely with the dental status and the quantity of plaque on the surface of teeth and dental implants. Once established, gingival hyperplasia makes it more difficult for the patient to maintain individual tooth cleaning and increases plaque formation. Thus proliferation of Gram-negative bacteria is enabled in the plaque which promotes gingival overgrowth and can pose a risk factor for further cardiovascular diseases. If proper individual oral hygiene and professional interventions are carried out, healthy and hyperplasia-free gingival state can be sustained in the long term in most cases, even with calcium channel blocker therapy. In order to protect patients' oral health, a closer cooperation of internists and dentists would be desirable. Orv Hetil. 2018; 159(29): 1183-1187.

Download full-text PDF

Source
http://dx.doi.org/10.1556/650.2018.31088DOI Listing

Publication Analysis

Top Keywords

gingival hyperplasia
16
calcium channel
16
oral health
8
cardiovascular diseases
8
gingival
6
[proper oral
4
health protect
4
protect developing
4
developing gingival
4
hyperplasia
4

Similar Publications

Introduction And Importance: Amlodipine is a third-generation calcium channel blocker used in the treatment of hypertension. One of the side effects associated with amlodipine is gingival hyperplasia mostly occurring at a higher dose (10 mg). There are very few cases of gingival hyperplasia associated with amlodipine at a lower dose (5 mg) or short-term administration.

View Article and Find Full Text PDF

Dentistry and Sturge-Weber syndrome: Case report and narrative review.

Spec Care Dentist

December 2024

Department of Basic Dental and Medical Science, College of Dentistry, University of Hail, Hail, Saudi Arabia.

Sturge-Weber syndrome (SWS) or encephalotrigeminal angiomatosis is a rare congenital disorder that affects the skin, brain, and eye. It is characterized by facial port-wine stains, leptomeningeal angiomas, and glaucoma. SWS can also cause neurological complications, such as seizures, headaches, cognitive impairment, and stroke.

View Article and Find Full Text PDF

Several attempts have been made to elucidate the pathogenesis of drug-induced gingival overgrowth (DIGO), which is triggered by the chronic use of certain drugs that fall into three main categories: anticonvulsants, immunosuppressants, and calcium channel blockers. Previous research suggests that cytokines and impaired cellular functions play a role in DIGO. Of particular interest are macrophages, immune cells that can switch between M1 (pro-inflammatory) and M2 (anti-inflammatory) phenotypes in response to exogenous signals and stimuli.

View Article and Find Full Text PDF

Segmental Odontomaxillary Dysplasia: Systematic Review.

Head Neck Pathol

October 2024

Oral Radiology Division, Faculdade São Leopoldo Mandic, Campinas, SP, Brazil.

Article Synopsis
  • This systematic review, guided by PRISMA and registered with PROSPERO, aimed to summarize current knowledge on segmental odontomaxillary dysplasia (SOD), including its characteristics and treatment options.
  • A total of 35 studies with 60 SOD cases were analyzed, showing a mean patient age of 12 years; males were more affected, and typical features included facial asymmetry, swelling, and various oral alterations.
  • The review found limited treatment options reported in the studies, highlighting a scarcity of evidence on effective management strategies for SOD.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!