Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/infdis/jiy384 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Anelloviruses and Cancer.
J Infect Dis
December 2024
San Diego Supercomputer Center, University of California, San Diego, California, USA.
Anelloviruses are among the most prevalent viruses within the human virome, detected in over 90% of healthy individuals. Despite their ubiquity, the role of anelloviruses in human health remains elusive. This review examines the potential associations of anelloviruses torque teno virus (TTV), torque teno midi virus (TTMDV), and torque teno mini virus (TTMV) with various cancers, highlighting the mixed conclusions from current epidemiological studies.
View Article and Find Full Text PDFImpact of induction agents and maintenance immunosuppression on torque teno virus loads and year-one complications after kidney transplantation.
Front Immunol
November 2024
Department of Nephrology, University Hospital Heidelberg, Heidelberg, Germany.
Article Synopsis
- Torque teno virus load (TTVL) is being studied as a way to measure immune health in kidney transplant patients, particularly how different medications affect TTVL levels.
- In a study of 134 patients, TTVL levels peaked at 90 days post-transplant and were significantly higher in those who received anti-thymocyte globulin (ATG) compared to interleukin-2 receptor antagonists (IL2-RA).
- Higher TTVL levels may indicate a greater risk of infections for patients, though this trend wasn't statistically significant, suggesting that monitoring TTVL could help manage immunosuppressive therapy post-transplant.
Clinical detection of four emerging canine diarrhea-associated viruses and evolutionary analysis of canine kobuvirus.
Arch Virol
November 2024
College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, 266109, P.R. China.
In this study, a multiplex PCR method was developed for the detection of four diarrhea-associated viruses of canines, including canine bocavirus (CBoV), canine circovirus (CCV), torque teno canis virus (TTCV), and canine kobuvirus (CKV). Four pairs of compatible primers, one specific for each virus, were designed based on conserved sequences. After optimization of parameters such as primer concentration and annealing temperature in single and multiple amplifications, four specific fragments were amplified simultaneously with high sensitivity and specificity in one PCR reaction.
View Article and Find Full Text PDFValidation, implementation and quality control of a Torque Teno Virus qPCR in a multinational clinical trial.
J Clin Virol
December 2024
Department of Microbiology and Infection Prevention, University of Groningen. University Medical Center Groningen, Groningen, The Netherlands.
Article Synopsis
- Immunosuppressive medication dosing after organ transplantation typically relies on therapeutic drug monitoring, but this method may not effectively predict rejection or infections.
- The TTVguideIT trial investigates using Torque Teno Virus (TTV) load measurement via qPCR as a potentially better alternative for dosing tacrolimus.
- Results demonstrated that the TTV R-GENE® assay showed excellent accuracy and consistency across participating labs, allowing for standardized TTV load measurement in clinical trials.
Torque Teno Virus Control by the Classical Pathway of Complement Activation-A Retrospective Analysis From a First-in-Human Trial Utilizing Sutimlimab.
J Med Virol
November 2024
Department of Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria.
Torque Teno virus (TTV) load is linked with the functionality of its host's immune system and has been proposed as a potential monitoring tool for immune-modulating therapy. However, the immunological mechanisms of TTV control are incompletely understood. To assess the effect of the classical complement pathway on TTV, 64 healthy volunteers and 10 kidney transplant recipients treated with the anti-C1s antibody sutimlimab were analyzed for serum TTV copy numbers (c/mL) by qPCR.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!