Magnetic resonance imaging (MRI) provides excellent cross-sectional images of the soft tissues in patients. Unfortunately, MRI is intrinsically slow, it exposes patients to severe acoustic noise levels, and is limited in the visualization of certain tissues such as bone. These limitations are partly caused by the timing structure of the MRI exam which first generates the MR signal by a strong radio-frequency excitation and later acquires the weak MRI signal. Concurrent excitation and acquisition (CEA) can overcome these limitations, but is extremely challenging due to the huge intensity difference between transmit and receive signal (up to 100 dB). To suppress the strong transmit signals during signal reception, a fully automated analog cancellation unit was designed. On a 3 Tesla clinical MRI system we achieved an on-resonance analog isolation of 90 dB between the transmit and receive path, so that CEA images of the head and the extremities could be acquired with an acquisition efficiency of higher than 90% at sound pressure levels close to background noise. CEA with analog cancellation might provide new opportunities for MRI in tissues with very short T relaxation times, and it offers a silent and time-efficient MRI acquisition.
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http://dx.doi.org/10.1038/s41598-018-28894-w | DOI Listing |
J Psychiatr Res
December 2024
Department of Psychology, University of Wisconsin Milwaukee, USA. Electronic address:
Obsessive-Compulsive Disorder (OCD) is a heterogenous mental health condition that causes significant impairment and is often associated with poor treatment outcomes. The aim of the current study was to examine the association between electroencephalographic (EEG) oscillatory power during inhibitory task performance and obsessive-compulsive symptoms (OCS). OCS was assessed using the well-established the Autogenous-Reactive Obsession (AO-RO) model as the main framework to address its heterogeneous clinical manifestations.
View Article and Find Full Text PDFCureus
November 2024
Department of Clinical Sciences, Lund University, Malmö, SWE.
J Chem Phys
September 2024
Center for Computational Molecular Science and Technology, School of Chemistry and Biochemistry, and School of Computational Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332-0400, USA.
Symmetry-adapted perturbation theory (SAPT) directly computes intermolecular interaction energy in terms of electrostatics, exchange-repulsion, induction/polarization, and London dispersion components. In SAPT based on Hartree-Fock ("SAPT0") or based on density functional theory, the most time-consuming step is the computation of the dispersion terms. Previous work has explored the replacement of these expensive dispersion terms with simple damped asymptotic models.
View Article and Find Full Text PDFA bandwidth-efficient coherent analog IFoF approach is proposed, employing a twin optical sideband (twin-OSSB) modulation of intermediate frequency-over-fiber (IFoF) signals in a dually modulated electroabsorption modulated laser (EML), demonstrating stable modulations without complex bias drifts and polarization control. The receiver (Rx) utilizes heterodyne detection with phase noise canceling (PNC) techniques for channel recovery. Successful demonstrations include an 8 Gbps aggregated twin-OSSB of two QPSK channels, with measurements covering optical back-to-back (btb) and 25 km of a standard single-mode fiber (SSMF), revealing sensitivities of -30 dBm and -25 dBm for QPSK-twin-OSSB and 16-QAM single user, respectively.
View Article and Find Full Text PDFAnticancer Res
September 2024
Department of Molecular Cancer Science, Yamagata University School of Medicine, Yamagata, Japan.
Background/aim: Glioblastoma is the most aggressive form of brain tumor and has a dismal prognosis; therefore, novel therapeutic approaches based on the mechanisms underlying its aggressive nature are urgently required. A growing body of evidence suggests that neurotransmitters play a key role in modulating the biology of glioblastoma; however, the role of melanocortins remains unclear.
Materials And Methods: The effects of bremelanotide, a melanocortin receptor agonist, alone or in combination with chemotherapeutic agents, on survivin expression and cell viability were investigated in human glioblastoma cell lines.
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