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State Variation in Uptake of Pharmacy-Based CLIA-Waived Testing: Impact of Laws and Regulations.
J Pharm Technol
December 2024
College of Pharmacy, Ferris State University and Collaboration to Advance Pharmacy Enterprises, Grand Rapids, MI, USA.
Community pharmacies have grown to be an increasingly important provider of CLIA-waived tests, just second to physician offices as the venue with the most waivers. Yet, individual variation is still observed across states with respect to the percentage of pharmacies holding a CLIA-waiver, with a reported range of 10.7% in Massachusetts to 87.
View Article and Find Full Text PDFHigh-altitude regions are prone to plateau erythrocytosis due to unique geo-climatic conditions such as low oxygen, high altitude, and low temperatures, with significantly higher incidences of hyperlipidemia and hyperuricemia compared to lowland areas. However, the extreme environmental conditions at high altitudes and the elevated hematocrit levels in blood samples from these populations present significant challenges to the applicability of existing point-of-care testing (POCT) devices. This study describes the development, early clinical validation, and potential clinical impact of three portable, paper-based photochemical biosensing platforms specifically designed for use at high altitudes to monitor hemoglobin, lipids, and uric acid in blood samples.
View Article and Find Full Text PDFCRISPR/Cas12a-Enabled Amplification-Free Colorimetric Visual Sensing Strategy for Point-of-Care Diagnostics of Biomarkers.
Anal Chem
December 2024
Cancer Research Center & Jiangxi Engineering Research Center for Translational Cancer Technology, Jiangxi University of Chinese Medicine & Jiangxi Province Key Laboratory for Diagnosis, Treatment and Rehabilitation of Cancer in Chinese Medicine, Nanchang, Jiangxi 330004, China.
CRISPR/Cas12a-based biosensors have garnered significant attention in the field of point-of-care testing (POCT), yet the majority of the CRISPR-based POCT methods employ fluorescent systems as report probes. Herein, we report a new CRISPR/Cas12a-enabled multicolor visual biosensing strategy for the rapid detection of disease biomarkers. The proposed assay provided vivid color responses to enhance the accuracy of visual detection.
View Article and Find Full Text PDFElectrochemical detection of extracellular vesicles for early diagnosis: a focus on disease biomarker analysis.
Extracell Vesicles Circ Nucl Acids
April 2024
Biotechnology and Food Engineering, Guangdong Technion-Israel Institute of Technology (GTIIT), Shantou 515063, Guangdong, China.
This review article presents a detailed examination of the integral role that electrochemical detection of extracellular vesicles (EVs) plays, particularly focusing on the potential application for early disease diagnostics through EVs biomarker analysis. Through an exploration of the benefits and challenges presented by electrochemical detection vetted for protein, lipid, and nucleic acid biomarker analysis, we underscore the significance of these techniques. Evidence from recent studies renders this detection modality imperative in identifying diverse biomarkers from EVs, leading to early diagnosis of diseases such as cancer and neurodegenerative disorders.
View Article and Find Full Text PDFNucleoside hydrogel-modified cell subtype biosensor with antifouling and electroconductive properties.
Talanta
December 2024
Materials Genome Institute and Shanghai Engineering Research Center of Organ Repair, Shanghai Engineering Research Center for Integrated Circuits and Advanced Display Materials, Shanghai University, Shanghai, 200444, PR China. Electronic address:
The point-of-care testing (POCT) of electrochemical biosensors is hindered by biofouling and signal sensitivity. Sometimes the antifouling strategies were used by decreasing the electroconductivity. Addressing the conductivity-antifouling trade-off in electrochemical sensors, we synthesized a novel conductive and antifouling nucleoside hydrogel (C-Ag-C hydrogel).
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