The abuse of amphetamine-type stimulants (ATS) has become a global public health issue in recent years, these new-type drugs can cause addiction and serious cognitive impairment. However, there are no effective methods for the prevention and treatment of ATS addiction at present. Repetitive transcranial magnetic stimulation (rTMS) is a painless and non-invasive new therapeutic approach that has been used for the treatment of depression and other neuropsychiatric disorders, but whether it can be used to treat drug addiction is unclear. In the present study, we investigated the possible effects of rTMS on methamphetamine(METH)-induced conditioned place preference (CPP). High-frequency (10 Hz) and low-frequency stimulation patterns (1 Hz) were applied to test the effect of rTMS on METH-induced CPP. The results showed that low-frequency but not high-frequency rTMS could block METH-CPP, accompanied with a downregulation of gamma-aminobutyric acid type B receptor subunit 1 (GABAR1) expression in rat dorsolateral striatum. These results suggested that low-frequency rTMS could effectively inhibit the development of METH addiction and shed light on the rTMS as a potential approach for the prevention of drug addiction.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bbr.2018.07.004 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effects of non-invasive brain stimulation on impulsivity in patients with mental disorders: a systematic review and meta-analysis of randomised clinical trials.
Gen Psychiatr
December 2024
Psychiatry Department, Universidade Federal de Minas Gerais Faculdade de Medicina, Belo Horizonte, Minas Gerais, Brazil.
Background: Non-invasive brain stimulation (NIBS) techniques, such as transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), may offer an alternative treatment strategy for impulsive behaviour. By modulating brain activity, these techniques could potentially enhance impulse control and mitigate impulsivity.
Aims: To provide a comprehensive analysis of the correlation between NIBS parameters, targeted brain regions and impulsivity.
Dysphagia in multiple sclerosis: pathophysiology, assessment, and management-an overview.
Front Neurol
December 2024
Unit of Neurology, IRCCS Neuromed, Pozzilli, Italy.
Dysphagia is a frequent and life-threatening complication of multiple sclerosis (MS). Swallowing disturbances may be present at all stages of MS, although their prevalence increases with age, with disease duration, and in progressive phenotypes. The pathophysiology of dysphagia in MS is likely due to a combination of factors, including the involvement of corticobulbar tracts, the cerebellum, and the brainstem.
View Article and Find Full Text PDFEffect Analysis of Early Rehabilitation Therapy Combined with Repetitive Transcranial Magnetic Stimulation on Postoperative Rehabilitation of Sports Knee Injury.
Sports Med Arthrosc Rev
October 2024
Department of Sport, Gdansk University of Physical Education and Sport, Gdansk 80-336, Poland.
Objective: To analyze the effectiveness of combined early rehabilitation therapy and repetitive transcranial magnetic stimulation (rTMS) in the postoperative rehabilitation of patients with sports knee injuries (SKI).
Methods: A total of 62 SKI patients from June 2021 to June 2022 were randomly selected by computer and divided into group A (31 cases, early rehabilitation therapy) and group B (31 cases, early rehabilitation therapy +rTMS) by numbered envelope method. The effects of the two groups were compared.
Effects of high-frequency repetitive transcranial magnetic stimulation of affected hemisphere on motor recovery in patients in the acute stage of ischemic stroke: Preliminary results .
Neuro Endocrinol Lett
December 2024
1st Department of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovakia Rehabilitation Centre Harmony, Bratislava, Slovakia.
Objectives: Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive neurostimulation technique that uses magnetic field to comprehensively influence events in the brain. Its use in patients after stroke focuses mainly on influencing brain neuroplasticity and therefore has the potential to improve motor functions in these patients. This study investigates the effect of rTMS on motor function recovery in patients in the acute stage of ischemic stroke.
View Article and Find Full Text PDFEfficacy of Repetitive Transcranial Magnetic Stimulation in Preventing Postoperative Delirium in Elderly Patients Undergoing Major Abdominal Surgery: A Randomized Controlled Trial.
Brain Stimul
December 2024
Department of Anesthesiology, The Affiliated Hospital of Nantong University, Nantong, 226001, China. Electronic address:
Background: Postoperative delirium (POD) is a serious complication in elderly patients after major surgery, associated with high morbidity and mortality. Treatment and prevention methods are limited. Repetitive transcranial magnetic stimulation (rTMS) shows potential in enhancing cognitive function and improving consciousness.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!