Background: According to epidemiologic studies, fine particulate matter (particulate matter ≤2.5 μm, PM2.5) is closely associated with increases in the incidence and severity of chronic rhinosinusitis (CRS). However, the role of PM2.5 in the pathophysiology of CRS remains largely unknown. In this study, we investigated the effects of PM2.5 on nasal cilia, tissue remodeling, and mucus hypersecretion in a rabbit model of CRS.
Methods: CRS rabbits were exposed to ambient PM2.5 via a PM2.5 inhalation exposure system. The degree of ciliary damage was evaluated using scanning electron microscopy (SEM). Histopathologic changes were determined using periodic acid-Schiff (PAS) staining of goblet cells and Masson trichrome (MT) staining for collagen in the nasal mucosa. MUC5AC expression was assessed by immunohistochemistry.
Results: PM2.5 exposure substantially aggravated ciliary disruption in rabbits with CRS. PM2.5 also significantly increased goblet cell hyperplasia and collagen deposition, as reflected by PAS and MT staining. The nasal mucosa of CRS rabbits displayed markedly elevated MUC5AC expression after PM2.5 exposure.
Conclusion: Increases in ciliary disruption, nasal remodeling, and mucus hypersecretion may be the pathophysiologic mechanisms underlying the PM2.5-induced aggravation of CRS.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/alr.22182 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Spatiotemporal Patterns and Equity Analysis of Premature Mortality Due to Ischemic Heart Disease Attributable to PM Exposure in China: 2007-2022.
Toxics
August 2024
School of Geological Engineering and Geomatics, Chang'an University, Xi'an 710054, China.
Long-term exposure to PM pollution increases the risk of cardiovascular diseases, particularly ischemic heart disease (IHD). Current assessments of the health effects related to PM exposure are limited by sparse ground monitoring stations and applicable disease research cohorts, making accurate health effect evaluations challenging. Using satellite-observed aerosol optical depth (AOD) data and the XGBoost-PM25 model, we obtained 1 km scale PM exposure levels across China.
View Article and Find Full Text PDFMaternal Exposure to Environmental Air Pollution and Premature Rupture of Membranes: Evidence from Southern China.
Med Sci Monit
May 2024
Department of Maternal Health Care, Maternal and Child Health Hospital of Tongling, Tongling, Anhui, China (mainland).
BACKGROUND Exposure to air pollution (AP) during pregnancy is associated with pre-labor rupture of membranes (PROM). However, there is limited research on this topic, and the sensitive exposure windows remain unclear. The present study assessed the association between AP exposure and the risk of PROM, as well as seeking to identify the sensitive time windows.
View Article and Find Full Text PDFAmbient PM and specific sources increase inflammatory cytokine responses to stimulators and reduce sensitivity to inhibitors.
Environ Res
July 2024
Department of Environmental Medicine and Climate Science, Icahn School of Medicine at Mt. Sinai, New York, NY, USA; Institute for Climate Change, Environmental Health, and Exposomics, Icahn School of Medicine at Mt. Sinai, New York, NY, USA.
Ambient exposure to fine particulate matter (PM) is associated with increased morbidity and mortality from multiple diseases. Recent observations suggest the hypothesis that trained immunity contributes to these risks, by demonstrating that ambient PM sensitizes innate immune cells to mount larger inflammatory response to subsequent bacterial stimuli. However, little is known about how general and durable this sensitization phenomenon is, and whether specific sources of PM are responsible.
View Article and Find Full Text PDFPathogenic bacteria and fungi in bioaerosols from specialized hospitals in Shandong province, East China.
Environ Pollut
January 2024
College of Life Sciences, Shandong Normal University, Jinan 250014, China. Electronic address:
Bacteria and fungi are abundant and ubiquitous in bioaerosols in hospital environments. Understanding the distribution and diversity of microbial communities within bioaerosols is critical for mitigating their detrimental effects. Our knowledge on the composition of bacteria or fungi in bioaerosols is limited, especially the potential pathogens present in fine particulate matter (PM) from specialized hospitals.
View Article and Find Full Text PDFA multi-residue method for the analysis of organic pollutants released from atmospheric PM in simulated biological fluids: Inhalation bioaccessibility and bioavailability estimation.
Anal Chim Acta
November 2023
University of A Coruña, Grupo Química Analítica Aplicada (QANAP), University Institute of Research in Environmental Studies (IUMA), Department of Chemistry, Faculty of Sciences, Campus de A Coruña, s/n. 15071, A Coruña, Spain.
Background: In recent decades, there has been a growing interest within the scientific community regarding the study of the fraction that could be released in simulated biological fluids to estimate in vitro bioaccessibility and bioavailability of compounds. Concerning particulate matter (PM), studies were essentially focused on metal (oid)s probably due to more complex methodologies needed for organic compounds, requiring extraction and pre-concentration steps from simulated fluids, followed by chromatographic analysis. Thus, the development of a simple and sensitive methodology for the analysis of multi-class organic compounds released in different inhalation simulated fluids would represent a great contribution to the field.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!