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http://dx.doi.org/10.1056/NEJMc1806186 | DOI Listing |
Behav Brain Res
January 2025
Laboratorio de Neurobiología del Sueño, Departamento de Fisiología, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
Ketamine is an NMDA receptor antagonist that has antidepressant and anesthetic properties. At subanesthetic doses, ketamine induces transient psychosis in humans, and is used to model psychosis in experimental animals. In rodents, subanesthetic doses of ketamine increase the power of high-frequency oscillations (HFO, > 100 Hz) in the electroencephalogram (EEG), a frequency band linked to cognitive functions.
View Article and Find Full Text PDFNeurosci Biobehav Rev
October 2024
Brain and Consciousness Independent Research Center, Andijan 710132, Uzbekistan. Electronic address:
A resurgence of panpsychism and dualism is a matter of ongoing debate in modern neuroscience. Although metaphysically hostile, panpsychism and dualism both persist in the science of consciousness because the former is proposed as a straightforward answer to the problem of integrating consciousness into the fabric of physical reality, whereas the latter proposes a simple solution to the problem of free will by endowing consciousness with causal power as a prerequisite for moral responsibility. I take the Integrated Information Theory (IIT) as a paradigmatic exemplar of a theory of consciousness (ToC) that makes its commitments to panpsychism and dualism within a unified framework.
View Article and Find Full Text PDFPresented here is a novel graphical, structural, and functional model of the embodied mind. Despite strictly adhering to a physicalistic and reductionist approach, this model successfully resolves the apparent contradiction between the thesis regarding the causal closure of the physical realm and the widely held common-sense belief that the mental realm can influence physical behavior. Furthermore, it substantiates the theory of mind-brain identity while shedding light on its neural foundation.
View Article and Find Full Text PDFIEEE Trans Neural Syst Rehabil Eng
August 2024
Assessing communication abilities in patients with disorders of consciousness (DOCs) is challenging due to limitations in the behavioral scale. Electroencephalogram-based brain-computer interfaces (BCIs) and eye-tracking for detecting ocular changes can capture mental activities without requiring physical behaviors and thus may be a solution. This study proposes a hybrid BCI that integrates EEG and eye tracking to facilitate communication in patients with DOC.
View Article and Find Full Text PDFCommun Biol
July 2024
Groupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives-UMR 5293, CNRS, CEA University of Bordeaux, Bordeaux, France.
Consciousness, a cornerstone of human cognition, is believed to arise from complex neural interactions. Traditional views have focused on localized fronto-parietal networks or broader inter-regional dynamics. In our study, we leverage advanced fMRI techniques, including the novel Functionnectome framework, to unravel the intricate relationship between brain circuits and functional activity shaping visual consciousness.
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