AI Article Synopsis
- The study investigates the biomechanical factors contributing to heart failure types: preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF).
- Diastolic myocardial stiffness was found to be significantly higher in HFrEF patients compared to both HFpEF and control groups, indicating a potential biomechanical difference in heart failure types.
- Personalised biomechanical models offer better insights into myocardial mechanics than traditional measurements like chamber stiffness, which do not effectively differentiate between heart failure groups due to geometric variations.
Article Abstract
Understanding the aetiology of heart failure with preserved (HFpEF) and reduced (HFrEF) ejection fraction requires knowledge of biomechanical factors such as diastolic myocardial stiffness and stress. Cine CMR images and intra-ventricular pressure recordings were acquired in 8 HFrEF, 11 HFpEF and 5 control subjects. Diastolic myocardial stiffness was estimated using biomechanical models and found to be greater in HFrEF (6.4 ± 1.2 kPa) than HFpEF (2.7 ± 0.6 kPa, p < 0.05) and also greater than control (1.2 ± 0.4 kPa, p < 0.005). End-diastolic mid-ventricular myofibre stress derived from the personalised biomechanics model was higher in HFrEF (2.9 ± 0.3 kPa) than control (0.9 ± 0.3 kPa, p < 0.01). Chamber stiffness, measured from the slope of the diastolic pressure-volume relationship, is determined by the intrinsic tissue properties as well as the size and shape of the heart, and was unable to distinguish between any of the three groups (p > 0.05). Personalised biomechanical analysis may provide more specific information about myocardial mechanical behaviour than global chamber indices, which are confounded by variations in ventricular geometry.
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| http://dx.doi.org/10.1007/s12265-018-9816-y | DOI Listing |
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