This study uses commercial claims database data to characterize trends in testosterone prescribing in the United States from 2002 to 2016.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396809 | PMC |
| http://dx.doi.org/10.1001/jama.2018.7999 | DOI Listing |
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Community pharmacy's role in dispensing androgens and supporting harm reduction amid current policy dilemmas.
Subst Abuse Treat Prev Policy
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Griffith Centre for Mental Health, Griffith University, Brisbane, QLD, Australia.
Background: Legitimate androgen use, such as testosterone replacement therapy, requires a legal prescription. Off-label use for reasons like wellness and aesthetics continues to grow. Recent regulatory changes in Australia aim to curb non-prescribed androgen use, potentially intensifying stigma, however seeking prescriptions through legal channels persists.
View Article and Find Full Text PDFDose-Response Effects of Exercise and Testosterone Replacement Therapy on Body Composition, Lean Mass, and Heart Rate Responses: A Case Report Using Wearable Technology.
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December 2024
College of Health Care Sciences, Nova Southeastern University, Fort Lauderdale, USA.
The case report explores the effects of testosterone replacement therapy (TRT) on body composition, lean muscle mass, and fat mass, based on the dosage of TRT and exercise intensity in a 40-year-old male. The purpose of this case study was to evaluate the dose-response relationship of TRT and exercise on muscle hypertrophy and fat loss over an eight-month period, using a validated wrist-worn wearable fitness tracker to measure daily physical activity and heart rate (HR)-based exercise intensity. The patient, a trained male with 25 years of consistent exercise experience, reported notable declines in strength and increases in body fat despite maintaining a regular workout routine.
View Article and Find Full Text PDFEffect of bicalutamide on serum total testosterone concentration in transgender adults: a case series.
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Trans Health Research Group, Department of Medicine, University of Melbourne, Parkville, VIC 3052, Australia.
Background: There is interest in repurposing bicalutamide for gender-affirming hormone therapy, but little data regarding efficacy and safety in the transgender population.
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The therapeutic effects of curcumin on polycystic ovary syndrome by upregulating PPAR-γ expression and reducing oxidative stress in a rat model.
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Department of Gynecology and Obstetrics, Clinical Medical College and The First Affiliated Hospital of Chengdu Medical College, Chengdu, China.
Article Synopsis
- Polycystic ovary syndrome (PCOS) affects 8-13% of women in their reproductive years and is commonly treated with off-label drugs that can have side effects; this study investigates curcumin's therapeutic effects in a PCOS rat model.
- The PCOS model was created using dehydroepiandrosterone (DHEA), followed by curcumin treatment, which assessed changes in ovarian morphology, hormone levels, and oxidative stress markers.
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The relation between testosterone replacement therapy (TRT) and anterior cruciate ligament injury risk has garnered attention in recent orthopaedic research. With TRT's popularity on the rise, understanding its potential musculoskeletal risks is important for orthopaedic and sports medicine providers. Whereas some studies suggest an association, confounding variables such as activity level, number of hours of sports participation, dosing variations, physiological versus supraphysiological levels of testosterone, and individual patient characteristics may influence outcomes.
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