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| http://dx.doi.org/10.1159/000481538 | DOI Listing |
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Dasatinib-induced colitis in a patient with chronic myeloid leukaemia.
BMJ Case Rep
January 2025
Department of Digestive Health, Gold Coast University Hospital, Gold Coast, Australia, Gold Coast Hospital and Health Service, Southport, Queensland, Australia.
Dasatinib is a common treatment for chronic myeloid leukaemia with numerous side effects including gastrointestinal. We report a woman in her 50s who presented with haematochezia, weight loss and a positive faecal occult blood test. She was being treated for chronic myeloid leukaemia with dasatinib without the use of any concurrent medications, including non-steroidal anti-inflammatory drugs.
View Article and Find Full Text PDFDasatinib-induced haemorrhagic colitis in a child with acute lymphoblastic leukaemia.
J Paediatr Child Health
December 2024
Paediatric Gastroenterology, Hepatology and Nutrition Unit, Department of Paediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Proven Cytomegalovirus Colitis Associated with Dasatinib Administration in Two Pediatric Allogeneic Hematopoietic Stem Cell Transplantation Recipients.
Pediatr Gastroenterol Hepatol Nutr
July 2023
Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Article Synopsis
- - Gastrointestinal bleeding is a rare side effect of dasatinib, linked to issues like colitis and low platelet counts.
- - Two pediatric patients experienced GI bleeding while on dasatinib following stem cell transplants, both diagnosed with cytomegalovirus (CMV) colitis.
- - Only one patient received antiviral treatment, and the absence of this therapy led to recurring GI bleeding and treatment delays, suggesting that antiviral therapy could help minimize interruptions in dasatinib treatment for those with CMV colitis.
Dasatinib-induced Crohn's-like colitis.
J Clin Pathol
March 2023
Department of Laboratory Services, IRCCS Ospedale Policlinico San Martino, Genova, Liguria, Italy
Dasatinib is a second-generation multityrosine kinase inhibitor used in the first-line and second-line treatment of Philadelphia chromosome-positive leukaemia. The most frequent type of Dasatinib-induced intestinal injury is haemorrhagic colitis; other morphologic patterns include apoptotic colopathy, CD8+ T-cell-mediated colitis and non-specific colitis. Aim of this study is to describe a novel Crohn's-like histopathologic pattern of Dasatinib-induced colitis.
View Article and Find Full Text PDFResolution of bacteremia without antibiotic therapy in a 16-year-old adolescent with leukemia receiving maintenance chemotherapy.
IDCases
January 2022
Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
spp. have been reported to cause infections in patients with underlying conditions. However, the pathogenicity of this bacteria is unclear.
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