-Hydroxylated cores are ubiquitous in natural products. Herein, we disclose the first template assisted hydroxylation reaction. Experimental and studies helped us to gain valuable mechanistic insights, including the role of the hexafluoroisopropanol (HFIP) solvent, during C-H hydroxylation. The reactive intermediates, prior to the C-H activation, have been detected by spectroscopic techniques. Additionally, the C-O bond formation has been extended to -acetoxylation. The preparation of a phase II quinone reductase activity inducer and a resveratrol precursor illustrated the synthetic significance of the present strategy.
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| http://dx.doi.org/10.1039/c5sc04060d | DOI Listing |
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