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ProTide generated long-acting abacavir nanoformulations. | LitMetric
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ProTide generated long-acting abacavir nanoformulations.

Zhiyi Lin Nagsen Gautam Yazen Alnouti JoEllyn McMillan Aditya N Bade Howard E Gendelman Benson Edagwa

Chem Commun (Camb)

Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5880, USA.

Published: July 2018

Abacavir pronucleotide nanoformulations (NM3ABC) were prepared as a novel long acting slow effective release antiretroviral therapy. Single NM3ABC treatment of human monocyte-derived macrophages produced sustained intracellular carbovir-triphosphate and antiretroviral activities for up to 30 days.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063073PMC
http://dx.doi.org/10.1039/c8cc04708aDOI Listing

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