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Understanding the anatomical basis of anorectal fistulas and their surgical management: exploring different types for enhanced precision and safety.
Surg Today
January 2025
Department of Basic Medical Science, College of Medicine, Taibah University, Madinah, Saudi Arabia.
Anorectal fistulas remain one of the most challenging conditions in colorectal surgery and require precise anatomical knowledge for successful management. This comprehensive review synthesizes the current evidence on the anatomical foundations of fistula development and treatment, particularly focusing on the cryptoglandular hypothesis and its clinical implications. A systematic analysis of the recent literature has examined the relationship between anatomical structures and fistula formation, classification systems, diagnostic modalities, and therapeutic approaches.
View Article and Find Full Text PDF[Edible insects' proteome in the safety aspect of entomoprotein's food application].
Vopr Pitan
January 2025
Federal Research Centre of Nutrition, Biotechnology and Food Safety, 109240, Moscow, Russian Federation.
Currently, the Russian Federation is considering the possibility of using insects as food raw materials, which, first of all, is positioned as a source of complete protein, therefore, the methodology of safety assessment of such products should include studying the proteomic profile of entomoprotein. Proteome profiling of the insect-derived novel food opens fresh opportunities not only for assessing their safety, but also for developing methods of elimination of potentially allergenic proteins from the final product. Modern technological approaches aimed at destruction or modification of the structure of such proteins, namely chemical modification (glycosylation, phosphorylation, acylation) and complexation with polyphenols, anthocyanins and other compounds, along with wet and dry thermal exposure, hydrolysis, fermentation, irradiation, ultrasound or high hydrostatic pressure treatment, will provide the possibility of obtaining products with reduced allergenic potential.
View Article and Find Full Text PDF[The importance of the diet in the prevention of atherosclerosis progression].
Vopr Pitan
January 2025
Ufa University of Science and Technology, 450076, Ufa, Russian Federation.
The most common mechanism of the development of cardiovascular diseases is atherosclerosis, caused by genetic predisposition, hyperlipidemia, inflammation and metabolic disorders. Statins used in medicine inhibit endogenous cholesterol synthesis, but are characterized by diabetogenic effect, development of intolerance in 9.1%, and muscle symptoms in 10-25% of patients.
View Article and Find Full Text PDFVirtual environments as a novel and promising approach in (neuro)diagnosis and (neuro)therapy: a perspective on the example of autism spectrum disorder.
Front Neurosci
January 2025
Department of Experimental Pharmacology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland.
Over the last three decades, dynamically evolving research using novel technologies, including virtual environments (VEs), has presented promising solutions for neuroscience and neuropsychology. This article explores the known and potential benefits and drawbacks of employing modern technologies for diagnosing and treating developmental disorders, exemplified by autism spectrum disorder (ASD). ASD's complex nature is ideal for illustrating the advantages and disadvantages of the digital world.
View Article and Find Full Text PDFFasting for male fertility-a mixed methods study.
Front Nutr
January 2025
Institute of Social Medicine, Epidemiology, and Health Economics, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Purpose: Approximately 10-20% of couples in Germany are unable to conceive. About 50% of this subfertility can be attributed to the male partner. Preclinical studies suggest that fasting could potentially influence central mechanisms of spermatogenesis.
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