The limited stability of catanionic vesicles has discouraged their wide use for encapsulation and controlled release of active substances. Their structure can easily break down to form lamellar phases, micelles or rearrange into multilamellar vesicles, as a consequence of small changes in their composition. However, despite the limited stability, catanionic vesicles possess an attractive architecture, which is able to efficiently encapsulate both hydrophobic and hydrophilic molecules. Therefore, improving the stability of the vesicles, as well as the control on unilamellar structures, are prerequisites for their wider application range. This study focuses on the impact of β-cyclodextrins for the stabilization of SDS/CTAB catanionic vesicles. Molar ratio and sample preparation procedures have been investigated to evaluate the temperature stability of catanionic vesicles. Diffusion and spectroscopic techniques evidenced that when β-cyclodextrins are added, unilamellar structures are stabilized above the multilamellar-unilamellar vesicles critical temperature. The results evidence encouraging perspectives for the use of vesicular nanoreservoirs for drug depot applications.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijpharm.2018.07.026 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Innovative approaches to cationic and anionic (catanionic) amphiphiles self-assemblies: Synthesis, properties, and industrial applications.
Adv Colloid Interface Sci
December 2024
Department of Chemistry and Centre for Advance Study in Chemistry, Panjab University, Chandigarh, India. Electronic address:
Meeting the contemporary demand for the development of functional, biocompatible, and environment friendly self-assembled structures using efficient, cost-effective, and energy-saving methods, the field of colloids has witnessed a surge in interest. Research into cationic and anionic (catanionic) surfactant combinations has gained momentum due to their distinct advantages and synergistic properties in this context. Catanionic self-assemblies have emerged as promising contenders for addressing these requirements.
View Article and Find Full Text PDFCascade Synthesis in Water: Michael Addition/Hemiketalization/Retro-Claisen Fragmentation Catalyzed by CatAnionic Vesicular Nanoreactor from Dithiocarbamate.
Chem Asian J
October 2024
Green Chemistry for Fine Chemical Production and Environmental Remediation Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Phayathai Road, Pathumwan, Bangkok, 10330, Thailand.
N,N-didodecylammonium N,N-didodecyldithiocarbamate (AmDTC-CC) underwent self-assembly to form a CatAnionic vesicular nanoreactor in water. AmDTC-CC can be readily prepared by condensation between N,N-didodecylamine and carbon disulfide. Previously, the cascade Michael addition/hemiketalization/retro-Claisen fragmentation was reported, but it required petroleum-based organic solvents as reaction media.
View Article and Find Full Text PDFStructure and Characterization of Catanionic Complexes and Biocompatible Vesicles of -Acyltaurine and Sarcosine Alkyl Ester: Encapsulation and Release Studies with 5-Fluorouracil.
ACS Appl Bio Mater
September 2024
School of Chemistry, University of Hyderabad, Hyderabad-500046, Telangana, India.
Hydrated dispersions containing equimolar mixtures of cationic and anionic amphiphiles, referred to as catanionic systems, exhibit synergistic physicochemical properties, and mixing single-chain cationic and anionic lipids can lead to the spontaneous formation of vesicles as well as other phase structures. In the present work, we have characterized two catanionic systems prepared by mixing -acyltaurines (NATs) and sarcosine alkyl esters (SAEs) bearing 11 and 12 C atoms in the acyl/alkyl chains. Turbidimetric and isothermal titration calorimetric studies revealed that both NATs form equimolar complexes with SAEs having matching acyl/alkyl chains.
View Article and Find Full Text PDFVesicle-micelle transitions driven by ROS, light and heat.
Nanoscale
September 2024
Department of Chemical & Biomolecular Engineering, University of Maryland, College Park, Maryland 20742, USA.
Article Synopsis
- Vesicles are tiny self-assembled containers capable of holding drugs, and researchers are keen on manipulating their structure to release these drugs when triggered.
- The study focuses on using reactive oxygen species (ROS), which are abundant near tumors, to initiate a transformation in these vesicles, enabling drug release.
- The vesicles are created by mixing two specific compounds in water, and their response to ROS, light, and temperature is confirmed through various scientific methods, highlighting the mechanisms behind these transformations.
Phosphate-Based Amphiphile and Lipidated Lysine Assemble into Superior Protocellular Membranes over Carboxylate and Sulfate-Based Systems: A Potential Missing Link between Prebiotic and the Modern Era?
Langmuir
December 2023
Indian Institute of Science Education and Research Kolkata, Nadia, Mohanpur 741246, West Bengal, India.
Amphiphiles are among the most extensively studied building blocks that self-assemble into cell-like compartments. Most literature suggested that the building blocks/amphiphiles of early Earth (fatty acid-based membrane) were much simpler than today's phospholipids. To establish the bridge between the prebiotic fatty acid era and the modern phospholipid era, the investigation and characterization of alternate building blocks that form protocellular membranes are necessary.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!