Drug delivery to the brain is challenging due to the presence of the blood-brain barrier. Mathematical modeling and simulation are essential tools for the deeper understanding of transport processes in the blood, across the blood-brain barrier and within the tissue. Here we present a mathematical model for drug delivery through capillary networks with increasingly complex topologies with the goal to understand the scaling behavior of model predictions on a coarse-to-fine sequence of grids. We apply our model to the delivery of L-Dopa, the primary drug used in the therapy of Parkinson's Disease. Our model replicates observed blood flow rates and ratios between plasma and tissue concentrations. We propose an optimal network grain size for the simulation of tissue volumes of 1 cm3 that allows to make reliable predictions with reasonable computational costs.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039031 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0200266 | PLOS |
Publication Analysis
Top Keywords
Similar Publications
Glia control experience-dependent plasticity in an olfactory critical period.
Elife
January 2025
Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, United States.
Sensory experience during developmental critical periods has lifelong consequences for circuit function and behavior, but the molecular and cellular mechanisms through which experience causes these changes are not well understood. The antennal lobe houses synapses between olfactory sensory neurons (OSNs) and downstream projection neurons (PNs) in stereotyped glomeruli. Many glomeruli exhibit structural plasticity in response to early-life odor exposure, indicating a general sensitivity of the fly olfactory circuitry to early sensory experience.
View Article and Find Full Text PDFCross-cultural validity of the Five-Factor Personality Inventory for ICD-11 across nine countries and validation of a French translation.
Personal Disord
January 2025
Laboratoire sur les Interactions Cognition, Action, Émotion (LICAE), UFR STAPS, Universite Paris-Nanterre.
This study aimed to assess measurement invariance for the Five-Factor Inventory for (Oltmanns & Widiger, 2020) across nine national samples from four continents ( = 6,342), and to validate a French translation in seven French-speaking national samples. All were convenience samples of adults. Exploratory factor analyses supported a four-factor structure in the French-speaking Western samples (Belgium, Canada, France, and Switzerland) while a three-factor structure was preferred in the French-speaking African samples (Burkina Faso and Togo), and no adequate structure was found in the Indian sample.
View Article and Find Full Text PDFDevelopment and validation of an MMPI-3 Antagonism scale.
Personal Disord
January 2025
Department of Psychological Science, Kent State University.
Antagonism is a personality domain located in most major trait models and is central to multiple personality disorders. This construct has been linked to many societally harmful externalizing behaviors (e.g.
View Article and Find Full Text PDFAssociation of multidimensional schizotypy with cognitive-behavioral disorganization in daily life: An experience sampling methodology study.
Personal Disord
January 2025
Department of Psychology, University of Illinois at Urbana-Champaign.
Schizotypy is a multidimensional construct that is composed of positive, negative, and disorganized dimensions. Historically, disorganized schizotypy, which involves disruptions in thoughts, speech, behavior, and affect, has been relatively understudied and less clearly operationalized than the other dimensions. The present study employed experience sampling methodology to examine the associations of positive, negative, and disorganized schizotypy, as measured by the Multidimensional Schizotypy Scale, with daily life experiences.
View Article and Find Full Text PDFExploring the influence of health and digital health literacy on quality of life and follow-up compliance in patients with primary non-muscle invasive bladder cancer: a prospective, single-center study.
World J Urol
January 2025
School of Medicine, Department of Urology, Istanbul Medeniyet University, Göztepe Prof. Dr. Süleyman Yalçın City Hospital, Fahrettin Kerim Gökay Cd., Istanbul, 34720, Turkey.
Objective: Given the increasing significance of digital health literacy (DHL) and health literacy (HL) in promoting informed decision-making and healthy behaviors, this study aimed to assess the influence of self-reported HL and DHL on treatment adherence and quality of life among patients who underwent transurethral resection of bladder tumors (TUR-BT) for primary non-muscle invasive bladder cancer (NMIBC).
Materials & Methods: This single-center observational study involved patients who underwent TUR-BT for NIMBC at a tertiary hospital from May 2022 to February 2024. Before the procedure, the patients' DHL and HL were evaluated using the European Health Literacy Survey Questionnaire short version and the eHealth Literacy Scale.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!