We have constructed versatile drug-loaded nanoprobes capable of responding to both MUC1 and telomerase and achieving intracellular drug release. Besides, the synthesized drug-loaded nanoprobes can realize the in situ imaging observation of the whole process of nanoprobes targeting the tumor cell membrane, the transmembrane entering the cytoplasm and the release of DOX into the cell nucleus.
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- Researchers have created a new cancer nanotherapy that has high safety, stability, and minimal toxicity, activated by the tumor environment for selective imaging and treatment.
- The nanoassembly features specially designed DNA components and targeted molecules that allow it to identify and attack tumor cells effectively, releasing drugs in response to the acidic conditions typical of tumors.
- The study demonstrates that this innovative nanoprobe can detect pH changes and combine multiple therapeutic strategies, highlighting its potential for improved cancer diagnosis and treatment.
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