A 6-month-old, 4-kg, dehydrated girl, an Indian native, was admitted with recurrent episodes of diarrhea that had occurred since age 2 months. She had stopped breastfeeding. She had also had concomitant vomiting and loss of appetite. Later, the mother noticed progressively increasing erythematous eruptions around the anogenital and the oral region. The baby had been born to a short-stature mother and was delivered by lower segment cesarean section. Regular antenatal follow-up was normal.

Download full-text PDF

Source

Publication Analysis

Top Keywords

acrodermatitis enteropathica
4
enteropathica presenting
4
presenting recurrent
4
recurrent diarrhea
4
diarrhea vomiting
4
vomiting infant
4
infant reluctant
4
reluctant breastfeed
4
breastfeed peculiar
4
peculiar erythemato-eczematous
4

Similar Publications

Objectives: Acrodermatitis dysmetabolica (AD) is a dermatologic manifestation associated with inherited metabolic disorders (IMDs), distinct from acrodermatitis enteropathica, which occurs solely due to zinc deficiency.

Case Presentation: This report presents two pediatric cases: a 30-month-old girl with maple syrup urine disease (MSUD) experiencing AD secondary to severe isoleucine deficiency due to a protein-restricted diet, showing improvement with dietary adjustments, and a 2.5-month-old boy infant with propionic acidemia (PA) who developed AD alongside septic shock, which progressed despite intervention.

View Article and Find Full Text PDF

ZIP4, a pivotal member of the ZIP family, is the causative gene for the hereditary disorder AE (acrodermatitis enteropathica) in humans, and plays an essential role in regulating zinc ion balance within cells. While research on the molecular structure of ZIP4 continues, there remains a lack of full understanding regarding the stereo-structural conformation of ZIP4 molecules. Currently, there are two hypotheses concerning the transport of zinc ions into the cytoplasm by ZIP4, with some contradictions between experimental studies.

View Article and Find Full Text PDF

Zinc Supplementation for Acrodermatitis Enteropathica Overlapped with Psoriasiform Lesions.

Psoriasis (Auckl)

November 2024

Department of Dermatology, Naval Medical Centre, Naval Medical University, Shanghai, 200052, People's Republic of China.

Acrodermatitis enteropathica (AE) can be caused by inherited or acquired zinc deficiency, among which site-specific skin lesions or even psoriasiform skin manifestations are present. Few cases exist in the literature involving the diagnosis and treatment of AE overlapped with psoriasiform lesions. In this case, we reported a teenage boy presented characteristic site-specific skin lesions of AE with low serum zinc level, subsequently progressed into generalized pustular psoriasiform manifestations under a genetic background, while a rapid recovery was observed after monotherapy of zinc supplementation.

View Article and Find Full Text PDF
Article Synopsis
  • A two-year-old girl experienced misdiagnoses such as tinea corporis and psoriasis, leading to ineffective treatments until a proper evaluation revealed her low zinc levels.
  • After being diagnosed with AE, she was treated with zinc sulfate, resulting in the complete resolution of her skin lesions within two weeks.
View Article and Find Full Text PDF

Acquired and Inherited Zinc Deficiency-Related Diseases in Children: A Case Series and a Narrative Review.

Pediatr Rep

July 2024

Pediatric Emergency Room and Emergency Medicine Unit, Emergency Department, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.

Article Synopsis
  • - Zinc deficiency is a critical health issue for children, leading to a variety of health problems and conditions that can be either acquired or inherited.
  • - This overview highlights the different symptoms, diagnostic difficulties, and treatment options for zinc deficiency in children, including issues like skin problems, slow growth, immune dysfunction, and neurological effects.
  • - Addressing zinc deficiency requires collaboration among healthcare professionals such as pediatricians, dermatologists, geneticists, and nutritionists to improve care and outcomes for affected children.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!