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Transcriptional phenotype of the anti-parasitic benzodiazepine meclonazepam on the blood fluke .
bioRxiv
November 2024
Department of Pathobiological Sciences, University of Wisconsin - Madison, Madison, WI, USA.
There are limited control measures for the disease schistosomiasis, despite the fact that infection with parasitic blood flukes affects hundreds of millions of people worldwide. The current treatment, praziquantel, has been in use since the 1980's and there is a concern that drug resistance may emerge with continued monotherapy. Given the need for additional antischistosomal drugs, we have re-visited an old lead, meclonazepam.
View Article and Find Full Text PDFRetained intracardiac air in cardiovascular surgery: a re-visited problem.
Gen Thorac Cardiovasc Surg
July 2024
Liaison Healthcare Engineering Section, Kochi Medical School, Kohasu, Oko-cho, Nankoku, Kochi, 783-8505, Japan.
Intracardiac air remains an unsolved problem in the realm of cardiac surgery, leading to embolic events encompassing conduction disturbance, heart failure, and stroke. Transesophageal echocardiography allows the visualization of three distinct types of retained intracardiac air: pooled air, coarse bubbles, and microbubbles. The former two predominantly manifest in the right upper pulmonary vein, left atrium, and left ventricle, exhibiting passive movement along the vessel walls by buoyancy.
View Article and Find Full Text PDFNimodipine accelerates the restoration of functional hyperemia during spreading oligemia.
J Neurochem
May 2024
Hungarian Centre of Excellence for Molecular Medicine-University of Szeged, Cerebral Blood Flow and Metabolism Research Group, Szeged, Hungary.
Spreading depolarization (SD) is assumed to be the pathophysiological correlate of migraine aura, leading to spreading depression of activity and a long-lasting vasoconstriction known as spreading oligemia. Furthermore, cerebrovascular reactivity is reversibly impaired after SD. Here, we explored the progressive restoration of impaired neurovascular coupling to somatosensory activation during spreading oligemia.
View Article and Find Full Text PDFAntibiotic use in the community for humans and animals is high in Vietnam, driven by easy access to over-the counter medicines and poor understanding of the role of antibiotics. This has contributed to antibiotic resistance levels that are amongst the highest in the world. To address this problem, we developed a participatory learning and action (PLA) intervention.
View Article and Find Full Text PDFSurveillance for peri-elimination trachoma recrudescence: Exploratory studies in Ghana.
PLoS Negl Trop Dis
September 2021
Clinical Research Department, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Introduction: To date, eleven countries have been validated as having eliminated trachoma as a public health problem, including Ghana in 2018. Surveillance for recrudescence is needed both pre- and post-validation but evidence-based guidance on appropriate strategies is lacking. We explored two potential surveillance strategies in Ghana.
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