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Cardiac cells and mesenchymal stem cells derived extracellular vesicles: a potential therapeutic strategy for myocardial infarction.
Front Cardiovasc Med
December 2024
Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Despite improvements in clinical outcomes of acute myocardial infarction (AMI), mortality rates remain high, indicating the need for further understanding of the pathogenesis and developing more effective cardiac protection strategies. Extracellular vesicles (EVs) carry proteins and noncoding RNAs (ncRNAs) derived from different cardiac cell populations, mainly including cardiomyocytes, endothelial cells, endothelial progenitor cells, cardiac progenitor cells, cardiosphere-derived cells, immune cells, fibroblasts and cardiac telocytes have vital roles under both physiological and pathological process such as myocardial infarction (MI). The content of EVs can also indicate the status of their parental cells and serve as a biomarker for monitoring the risk of cardiac injury.
View Article and Find Full Text PDFEight-Year Outcomes of Cardiosphere-Derived Cells in Single Ventricle Congenital Heart Disease.
J Am Heart Assoc
November 2024
Department of Regenerative Medicine, Center for Innovative Clinical Medicine Okayama University Hospital Okayama Japan.
Article Synopsis
- A study was conducted to evaluate the long-term effects of Cardiosphere-derived cell (CDC) infusion in patients with single ventricle heart disease, focusing on outcomes over an 8-year period.
- Among 93 patients, those who received CDC infusion experienced a statistically significant reduction in late failure and adverse events compared to control patients, although overall survival rates at 8 years did not significantly differ.
- The beneficial effects of CDC treatment on survival became more apparent by the 4-year mark, particularly for patients with heart failure, suggesting that CDC infusion may provide sustained clinical advantages over time.
Deconstructing Regenerative Medicine: From Mechanistic Studies of Cell Therapy to Novel Bioinspired RNA Drugs.
Circ Res
September 2024
Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA.
All Food and Drug Administration-approved noncoding RNA (ncRNA) drugs (n≈20) target known disease-causing molecular pathways by mechanisms such as antisense. In a fortuitous evolution of work on regenerative medicine, my coworkers and I inverted the RNA drug discovery process: first we identified natural disease-modifying ncRNAs, then used them as templates for new synthetic RNA drugs. Mechanism was probed only after bioactivity had been demonstrated.
View Article and Find Full Text PDFThe cardiac perivascular niche is a cellular microenvironment of a blood vessel. The principles of niche regulation are still poorly understood. We studied the effect of TGFβ1 on cells forming the cardiac perivascular niche using 3D cell culture (cardiospheres).
View Article and Find Full Text PDFComparing fabrication techniques for engineered cardiac tissue.
J Biomed Mater Res A
November 2024
Graduate Program in Bioengineering and Small-scale Technologies, University of California, Merced, USA.
Tissue engineering can provide in vitro models for drug testing, disease modeling, and perhaps someday, tissue/organ replacements. For building 3D heart tissue, the alignment of cardiac cells or cardiomyocytes (CMs) is important in generating a synchronously contracting tissue. To that end, researchers have generated several fabrication methods for building heart tissue, but direct comparisons of pros and cons using the same cell source is lacking.
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