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Longitudinal Follow-up Reveals Peripheral Immunological Changes Upon Tick Bite in a-Gal-Sensitized Individuals.
J Investig Allergol Clin Immunol
November 2024
Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Background And Objectives: α-Gal syndrome is characterized by specific IgE (sIgE) antibodies to the carbohydrate galactose-α-1,3-galactose (α-Gal) and delayed onset of allergic symptoms after ingestion of mammalian meat. While tick bites are assumed to mediate sensitization, the immune response to tick bites has not yet been investigated. To investigate the peripheral immune response to tick bites in humans over time.
View Article and Find Full Text PDFShort-course subcutaneous treatment with birch pollen allergoids greatly improves symptom and medication scores in birch allergy.
Allergy
November 2024
Department of Otorhinolaryngology, Technische Universität Dresden, Dresden, Germany.
Background: Subcutaneous immunotherapy has emerged as an effective option for treating allergic diseases. Here, we assessed the clinical impact of the mannan-conjugated birch pollen polymerized allergoid T502 in birch pollen-induced allergic rhinoconjunctivitis.
Methods: In this prospective, randomized, double-blind placebo-controlled phase III trial, 298 birch pollen-allergic adult patients were treated across 28 trial sites in Germany.
Hypersensitivity pneumonitis to phthalic anhydride: Case description and review of the literature.
Allergol Select
August 2024
Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), and.
Article Synopsis
- Hypersensitivity pneumonitis (HP) is an uncommon lung allergy primarily caused by inhaling organic dusts, with rare instances linked to chemicals like phthalates found in plastics.
- A clinical case involving a cable production worker demonstrated that symptoms initially diagnosed as idiopathic pulmonary fibrosis were linked to chronic HP resulting from exposure to phthalates, confirmed by specific IgG antibodies and other clinical findings.
- The study highlights the need for greater awareness of phthalates as potential triggers for occupational HP, as it has not been commonly recognized in previous case reports.
Biomarkers for a less invasive strategy to predict children with eosinophilic esophagitis.
Allergy
December 2024
Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Background: Noninvasive biomarkers for diagnosing and monitoring eosinophilic esophagitis (EoE) are currently lacking. This study evaluates 20 biomarkers in serum and saliva, aiming to assess their diagnostic potential in pediatric EoE patients and healthy individuals.
Methods: Blood and saliva from children undergoing upper endoscopy were analyzed for biomarkers, including absolute eosinophil count (AEC), eosinophil-derived neurotoxin (EDN), total and specific IgG-antibodies (sIgG), specific IgE-antibodies (sIgE) and 15-hydroxyeicosatetraenoic acid (15(S)-HETE).
The Evaluation Value of the Modified Lund-Kennedy Nasal Endoscopy Score on the Efficacy of Sublingual Immunotherapy for Allergic Rhinitis.
Am J Rhinol Allergy
November 2024
Department of Otolaryngology Head and Neck Surgery, Yongchuan Hospital of Chongqing Medical University, Chongqing, China.
Objective: Allergic rhinitis (AR) is a growing public health problem worldwide. Respecting the significance of the modified Lund-Kennedy (MLK) score in rhinitis assessment, we delved into its evaluation value on the sublingual immunotherapy (SLIT) efficacy in AR patients.
Methods: Totally 100 AR patients were enrolled, with pre- and post-SLIT MLK score, total nasal symptoms score (TNSS), total medication score (TMS), visual analogue scale (VAS), inflammatory cytokines, and immune function-related parameters compared.
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