AI Article Synopsis
- Several animal models, including a rabbit model, have been developed to study atherosclerosis.
- This rabbit model involves surgically removing the aortic endothelium and feeding the rabbits a high-fat, cholesterol-rich diet, leading to the formation of lesions similar to human atherosclerosis.
- The large size of rabbits allows for better imaging and evaluation of new treatment strategies using clinical scanners, and the chapter details the procedures and methods for inducing and assessing aortic atherosclerotic lesions.
Article Abstract
Several animal models have been developed to study atherosclerosis. Here we present a rabbit atherosclerosis model generated by surgical denudation of the aortic endothelium in combination with a high-fat and cholesterol-enriched diet. This model is characterized by the formation of vascular lesions that exhibit several hallmarks of human atherosclerosis. Due to the rabbit's relative large size, as compared to rodents, this model is suited for the imaging-guided evaluation of novel therapeutic strategies using clinical scanners. In this chapter, we present an extensive outline of the procedures to induce aortic atherosclerotic lesions in rabbits as well as methods to evaluate the disease, including noninvasive in vivo multiparametric imaging and histopathology.
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| http://dx.doi.org/10.1007/978-1-4939-8597-5_30 | DOI Listing |
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