Limbic encephalitis as a relapse of Whipple's disease with digestive involvement and spondylodiscitis.

Introduction: Many clinical manifestations can be related to Tropheryma whipplei infection.

Case Report: We report a Tropheryma whipplei limbic encephalitis developed as a relapse of classical Whipple's disease.

Discussion: This case is to the best of our knowledge the first proof of the effective brain-blood barrier crossing of both doxycycline and hydroxychloroquine as demonstrated by direct concentration monitoring on brain biopsy.